This article presents a protocol system, comprised of a review process and a series of checklists, that was developed for testing cadaveric tissue in an impact biomechanics research facility. The use of cadaveric tissue may expose personnel to bloodborne pathogens including HIV and hepatitis B, which have been shown to remain virulent in a cadaver for several weeks after death. To minimize exposure risks, the protocol system presented emphasizes initial blood screening to keep infectious tissue from entering the laboratory, and adopts universal precautions to prevent exposure by treating all tissue as though it were infected. All lab employees must read, sign, and demonstrate proficiency in the protocol. Well-developed test procedures for the handling of biohazardous materials along with an annual individual protocol review have proven effective for the past 6 years in minimizing exposure risks.