Pancreatic inflammation, apoptosis, and growth: sequential events after partial pancreatectomy in pigs

Pancreas. 2000 Oct;21(3):321-4. doi: 10.1097/00006676-200010000-00015.

Abstract

Positive signs of pancreas regeneration were observed in rats after induced pancreatitis and partial pancreatectomy (1,2). Although the human pancreas did not regenerate after partial anatomic resection (3), the pig pancreas exhibited growth responses to bombesin after partial pancreatectomy (4). This study was undertaken to establish the time course of pancreatic inflammation, apoptosis, and hypertrophy and/or hyperplasia after partial pancreatectomy in pigs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis*
  • DNA / analysis
  • Enzyme Activation
  • Female
  • Hyperplasia
  • Kinetics
  • Mitogen-Activated Protein Kinase 1 / metabolism
  • Mitogen-Activated Protein Kinase 3
  • Mitogen-Activated Protein Kinases / metabolism
  • Pancreas / pathology*
  • Pancreas / physiopathology
  • Pancreatectomy*
  • Pancreatitis*
  • Regeneration
  • Swine

Substances

  • DNA
  • Mitogen-Activated Protein Kinase 1
  • Mitogen-Activated Protein Kinase 3
  • Mitogen-Activated Protein Kinases