The role of different Scinderin domains in the control of F-actin cytoskeleton during exocytosis

T Lejen; T Dumitrescu Pene; S D Rosé; J-M Trifaró

doi:10.1111/j.1749-6632.2002.tb04469.x

The role of different Scinderin domains in the control of F-actin cytoskeleton during exocytosis

Ann N Y Acad Sci. 2002 Oct:971:248-50. doi: 10.1111/j.1749-6632.2002.tb04469.x.

Authors

T Lejen¹, T Dumitrescu Pene, S D Rosé, J-M Trifaró

Affiliation

¹ Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada. tlejen@uottawa.ca

PMID: 12438125
DOI: 10.1111/j.1749-6632.2002.tb04469.x

Abstract

Scinderin (Sc), a Ca(2+)-regulated actin-binding protein, has been previously shown to control submembranous actin dynamics in regulated secretion. The results of the present study suggest the possibility that Sc might act as a molecular switch in the control of cortical F-actin dynamics during secretion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actins / metabolism*
Animals
Binding Sites
Cell Membrane / metabolism
Chromaffin Cells / metabolism
Cytoskeleton / metabolism*
Cytosol / metabolism
Exocytosis*
Gelsolin
Microfilament Proteins / chemistry*
Microfilament Proteins / physiology*
Microscopy, Confocal
Protein Structure, Tertiary
Transfection

Substances

Actins
Gelsolin
Microfilament Proteins
scinderin