Lessons for human diabetes from experimental mouse models

Curr Diab Rep. 2003 Apr;3(2):168-75. doi: 10.1007/s11892-003-0041-x.

Abstract

A precise knowledge of the defects underlying type 1 and type 2 diabetes is essential for designing appropriate therapeutic strategies. Because experiments in humans are limited, naturally occurring, and especially genetically engineered rodent models, have revolutionized research in diabetes. We review some of the models created recently and discuss their impact on human diabetes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cytokines / genetics
  • Diabetes Mellitus, Type 1 / genetics
  • Diabetes Mellitus, Type 1 / immunology
  • Diabetes Mellitus, Type 1 / physiopathology*
  • Diabetes Mellitus, Type 1 / therapy*
  • Diabetes Mellitus, Type 2 / physiopathology*
  • Diabetes Mellitus, Type 2 / therapy
  • Disease Models, Animal
  • Genetic Therapy
  • Histocompatibility Antigens Class II / metabolism
  • Humans
  • Immune Tolerance
  • Insulin / metabolism
  • Islets of Langerhans / physiopathology
  • Mice
  • Mice, Transgenic

Substances

  • Cytokines
  • Histocompatibility Antigens Class II
  • Insulin