Abstract
Store-operated Ca(2+) channels (SOCs) are activated in response to Ca(2+) release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca(2+) content to the pore-forming SOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STIM1 in skeletal muscle, and a prominent role of SOCs in muscle development and function.
MeSH terms
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Animals
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Calcium / metabolism
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Calcium Channels / metabolism*
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Calcium Signaling
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Endoplasmic Reticulum / metabolism*
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Homeostasis
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Humans
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Intracellular Membranes
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Membrane Proteins / metabolism
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Models, Biological
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Muscle, Skeletal / metabolism*
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Muscle, Skeletal / pathology*
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Muscles / metabolism
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Neoplasm Proteins / metabolism
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ORAI1 Protein
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Stromal Interaction Molecule 1
Substances
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Calcium Channels
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Membrane Proteins
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Neoplasm Proteins
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ORAI1 Protein
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ORAI1 protein, human
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STIM1 protein, human
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Stromal Interaction Molecule 1
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Calcium