Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy

Clin Imaging. 2009 Jul-Aug;33(4):301-5. doi: 10.1016/j.clinimag.2009.01.013.

Abstract

Twenty-six patients with prostate cancer status post-radical prostatectomy who were candidates for salvage radiation therapy (SRT) underwent lymphotropic nanoparticle enhanced MRI (LNMRI) using superparamagnetic nanoparticle ferumoxtran-10. LNMRI was well tolerated, with only two adverse events, both Grade 2. Six (23%) of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on size criteria.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / diagnosis*
  • Adenocarcinoma / secondary*
  • Adenocarcinoma / surgery
  • Adult
  • Aged
  • Contrast Media
  • Dextrans
  • Ferrosoferric Oxide
  • Humans
  • Image Enhancement / methods*
  • Iron*
  • Lymph Nodes / pathology*
  • Lymphatic Metastasis
  • Magnetic Resonance Imaging / methods*
  • Magnetite Nanoparticles
  • Male
  • Nanoparticles*
  • Oxides*
  • Preoperative Care
  • Prostatectomy
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / surgery
  • Radiotherapy, Conformal
  • Reproducibility of Results
  • Salvage Therapy
  • Sensitivity and Specificity

Substances

  • Contrast Media
  • Dextrans
  • Magnetite Nanoparticles
  • Oxides
  • ferumoxtran-10
  • Iron
  • Ferrosoferric Oxide