Abstract
Twenty-six patients with prostate cancer status post-radical prostatectomy who were candidates for salvage radiation therapy (SRT) underwent lymphotropic nanoparticle enhanced MRI (LNMRI) using superparamagnetic nanoparticle ferumoxtran-10. LNMRI was well tolerated, with only two adverse events, both Grade 2. Six (23%) of the 26 patients, previously believed to be node negative, tested lymph node positive by LNMRI. A total of nine positive lymph nodes were identified in these six patients, none of which were enlarged based on size criteria.
Publication types
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Controlled Clinical Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenocarcinoma / diagnosis*
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Adenocarcinoma / secondary*
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Adenocarcinoma / surgery
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Adult
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Aged
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Contrast Media
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Dextrans
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Ferrosoferric Oxide
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Humans
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Image Enhancement / methods*
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Iron*
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Lymph Nodes / pathology*
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Lymphatic Metastasis
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Magnetic Resonance Imaging / methods*
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Magnetite Nanoparticles
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Male
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Nanoparticles*
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Oxides*
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Preoperative Care
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Prostatectomy
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Prostatic Neoplasms / diagnosis*
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Prostatic Neoplasms / surgery
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Radiotherapy, Conformal
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Reproducibility of Results
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Salvage Therapy
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Sensitivity and Specificity
Substances
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Contrast Media
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Dextrans
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Magnetite Nanoparticles
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Oxides
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ferumoxtran-10
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Iron
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Ferrosoferric Oxide