Abstract
Since its first characterization in the erythrocyte membrane the plasma membrane Ca(2+)-ATPase has been well-defined as a ubiquitous mechanism for the efflux of Ca(2+) from eukaryotic cells. With 4 isoforms and potentially 30 splice variants, defining the absolute physiological role of plasma membrane Ca(2+)-ATPase has been difficult and very limited due to the lack of effective blockers/antibodies and difficulties in measuring the activity of individual isoforms. This review highlights recent developments showing that specific plasma membrane Ca(2+)-ATPase isoforms are subject to dynamic regulation by PSD-95/Dlg/Zo-1 scaffold proteins. Such interactions support a new paradigm, that by serving as key players in multifunctional protein complexes, transporters can regulate other signalling processes independent of their primary ion pumping function.
Copyright 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Adaptor Proteins, Signal Transducing / metabolism*
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Animals
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Calcium Signaling
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Cell Membrane / enzymology
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Discs Large Homolog 1 Protein
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Disks Large Homolog 4 Protein
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Feedback, Physiological
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Guanylate Kinases
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Humans
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Intracellular Signaling Peptides and Proteins / metabolism*
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Isoenzymes / genetics
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Isoenzymes / metabolism*
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Membrane Proteins / metabolism*
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Multiprotein Complexes
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Phosphoproteins / metabolism*
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Plasma Membrane Calcium-Transporting ATPases / genetics
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Plasma Membrane Calcium-Transporting ATPases / metabolism*
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Zonula Occludens-1 Protein
Substances
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Adaptor Proteins, Signal Transducing
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DLG1 protein, human
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Discs Large Homolog 1 Protein
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Disks Large Homolog 4 Protein
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Dlg4 protein, mouse
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Intracellular Signaling Peptides and Proteins
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Isoenzymes
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Membrane Proteins
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Multiprotein Complexes
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Phosphoproteins
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TJP1 protein, human
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Tjp1 protein, mouse
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Zonula Occludens-1 Protein
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Guanylate Kinases
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Plasma Membrane Calcium-Transporting ATPases