Controlled ovarian hyperstimulation for low responders in in vitro fertilization/intracytoplasmic sperm injection: a low-dose flare protocol

Fertil Steril. 2011 Apr;95(5):1809-12. doi: 10.1016/j.fertnstert.2010.11.049. Epub 2010 Dec 18.

Abstract

In this retrospective study of 652 anticipated low response women, the overall clinical outcomes (live birth rate and clinical pregnancy rate [PR]) of low-dose flare (LDF) protocol appeared lower than those of conventional down-regulation (DR) (LDF: 15.1% vs. DR: 20.6% and LDF: 10.3% vs. DR: 17.4%, respectively). The findings that LDF protocol improved the clinical outcome in older women, or when LDF followed an unsuccessful IVF/intracytoplasmic sperm injection (ICSI) cycle with DR (LDF: 19.4% vs. DR: 9.76% and LDF: 13.9% vs. DR: 4.2% respectively), need further evaluation through randomized trials.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Birth Rate
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Fertility Agents, Female / administration & dosage*
  • Fertilization in Vitro* / methods
  • Humans
  • Infertility, Female / therapy*
  • Male
  • Ovulation Induction / methods*
  • Pregnancy
  • Pregnancy Rate
  • Retrospective Studies
  • Sperm Injections, Intracytoplasmic* / methods
  • Treatment Failure

Substances

  • Fertility Agents, Female