Abstract
A well-known nonsteroidal anti-inflammatory drug (NSAID), namely, naproxen (Np), was conjugated with β-alanine and various combinations of amino alcohols and l-alanine. Quite a few bioconjugates, thus synthesized, were capable of gelling pure water, NaCl solution (0.9 wt %), and phosphate-buffered saline (PBS) (pH 7.4). The hydrogels were characterized by rheology and electron microscopy. Hydrogelation was probed by FT-IR and temperature-variable (1)H NMR studies. Single-crystal X-ray diffraction (SXRD) of a nonhydrogelator and a hydrogelator in the series established a useful structure-property (gelation) correlation. MTT assay of the hydrogelators in the mouse macrophage RAW 264.7 cell line showed excellent biocompatibility. The prostaglandin E2 (PGE2) assay of the hydrogelators revealed their anti-inflammatory response, which was comparable to that of the parent NSAID naproxen sodium (Ns).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemistry*
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Amino Alcohols / chemistry*
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Biocompatible Materials / chemistry*
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Cell Line
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Dinoprostone / antagonists & inhibitors
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Dinoprostone / metabolism
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Dose-Response Relationship, Drug
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Hydrogels / chemistry*
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Interferon-gamma / antagonists & inhibitors
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Interferon-gamma / metabolism
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Lipopolysaccharides / antagonists & inhibitors
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects
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Macrophages / metabolism
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Mice
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Models, Molecular
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Molecular Structure
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Particle Size
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Surface Properties
Substances
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Amino Acids
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Amino Alcohols
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Anti-Inflammatory Agents, Non-Steroidal
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Biocompatible Materials
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Hydrogels
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Lipopolysaccharides
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Interferon-gamma
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Dinoprostone