Acetyl-CoA synthetase is a conserved regulator of autophagy and life span

Hamed Mirzaei; Valter D Longo

doi:10.1016/j.cmet.2014.03.021

Acetyl-CoA synthetase is a conserved regulator of autophagy and life span

Cell Metab. 2014 Apr 1;19(4):555-7. doi: 10.1016/j.cmet.2014.03.021.

Authors

Hamed Mirzaei¹, Valter D Longo²

Affiliations

¹ Longevity Institute, School of Gerontology and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA.
² Longevity Institute, School of Gerontology and Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, CA 90089, USA. Electronic address: vlongo@usc.edu.

Abstract

Autophagy is essential for the maintenance of cellular homeostasis during periods of stress. Eisenberg and colleagues (Eisenberg et al., 2014) now describe the central and conserved role for acetyl-CoA synthetase in regulating life span in yeast and flies by a mechanism involving autophagy.

Publication types

Comment

MeSH terms

Animals
Autophagy*
Coenzyme A Ligases / metabolism*
Drosophila Proteins / metabolism*
Longevity*

Substances

Drosophila Proteins
Coenzyme A Ligases

Abstract

Publication types

MeSH terms

Substances

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