Outcomes of orthotopic liver transplantation in non-malignant end-stage liver diseases

Y Sirivatanauksorn; N Kongkaewpaisan; A Pongpaibul; S Limsrichamrern; P Mahawithitwong; P Kositamongkol; C Tovikkai; S Asavakarn

doi:10.1016/j.transproceed.2014.02.026

Outcomes of orthotopic liver transplantation in non-malignant end-stage liver diseases

Transplant Proc. 2014 Apr;46(3):778-81. doi: 10.1016/j.transproceed.2014.02.026.

Authors

Y Sirivatanauksorn¹, N Kongkaewpaisan², A Pongpaibul³, S Limsrichamrern², P Mahawithitwong², P Kositamongkol², C Tovikkai², S Asavakarn²

Affiliations

¹ HepatoPancreatoBiliary and Transplant Surgery Unit, Division of General Surgery, Department of Surgery, Siriraj Organ Transplantation Center, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand. Electronic address: yongyut.sir@mahidol.ac.th.
² HepatoPancreatoBiliary and Transplant Surgery Unit, Division of General Surgery, Department of Surgery, Siriraj Organ Transplantation Center, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
³ Department of Pathology, Siriraj Organ Transplantation Center, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.

PMID: 24767347
DOI: 10.1016/j.transproceed.2014.02.026

Abstract

Background: Orthotopic liver transplantation (OLT) is an effective treatment for patients who have end-stage liver disease. The aim of this study is to compare outcomes of OLT in fulminant hepatic failure (FHF) and non-fulminant hepatic failure (non-FHF) patients.

Methods: A retrospective review of adult patients who underwent OLT for non-malignant end-stage liver diseases between 2002 and 2011 at Siriraj Hospital was performed. All explanted liver histopathology results were reviewed. The clinical factors and overall results of OLT were analyzed.

Results: Of the 137 patients, 72 patients had non-malignant diagnoses. Eleven patients were diagnosed with FHF, whereas 61 patients were in the non-FHF group. The most common indication for liver transplantation was chronic viral hepatitis. One- and 5-year survival rates (95% confidence interval) in the FHF group were 91% (51%-99%) and 91% (51%-99%), respectively, whereas those in the non-FHF group were 74% (61%-83%) and 66% (52%-77%), respectively. Multivariate cox regression analysis revealed no statistically significant difference of survival between both groups (P = .34).

Conclusions: The post-OLT outcomes in non-malignant patients were comparable between FHF and non-FHF groups in terms of survival. OLT remains the only therapeutic option for the FHF patients.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adult
End Stage Liver Disease / surgery*
Female
Humans
Liver Transplantation*
Male
Middle Aged
Retrospective Studies
Survival Rate
Treatment Outcome