The microenvironment matters: estrogen deficiency fuels cancer bone metastases

Laura E Wright; Theresa A Guise

doi:10.1158/1078-0432.CCR-14-0576

The microenvironment matters: estrogen deficiency fuels cancer bone metastases

Clin Cancer Res. 2014 Jun 1;20(11):2817-9. doi: 10.1158/1078-0432.CCR-14-0576. Epub 2014 May 6.

Authors

Laura E Wright¹, Theresa A Guise²

Affiliations

¹ Authors' Affiliations: Department of Medicine, Division of Endocrinology, Indiana University School of Medicine; and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana.
² Authors' Affiliations: Department of Medicine, Division of Endocrinology, Indiana University School of Medicine; and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IndianaAuthors' Affiliations: Department of Medicine, Division of Endocrinology, Indiana University School of Medicine; and Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana tguise@iu.edu.

Abstract

Factors released during osteoclastic bone resorption enhance disseminated breast cancer cell progression by stimulating invasiveness, growth, and a bone-resorptive phenotype in cancer cells. Postmenopausal bone loss may accelerate progression of breast cancer growth in bone, explaining the anticancer benefit of the bone-specific antiresorptive agent zoledronic acid in the postmenopausal setting. Clin Cancer Res; 20(11); 2817-9. ©2014 AACR.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Bone Neoplasms / secondary*
Breast Neoplasms / pathology*
Estrogens / deficiency*
Female
Humans
Mice
Osteoporosis, Postmenopausal*
Tumor Microenvironment*

Substances

Estrogens

Abstract

Publication types

MeSH terms

Substances

Grants and funding