Comparison of toxicity after IMRT and 3D-conformal radiotherapy for patients with pancreatic cancer - a systematic review

Martin-Immanuel Bittner; Anca-Ligia Grosu; Thomas B Brunner

doi:10.1016/j.radonc.2014.11.043

Comparison of toxicity after IMRT and 3D-conformal radiotherapy for patients with pancreatic cancer - a systematic review

Radiother Oncol. 2015 Jan;114(1):117-21. doi: 10.1016/j.radonc.2014.11.043. Epub 2014 Dec 11.

Authors

Martin-Immanuel Bittner¹, Anca-Ligia Grosu², Thomas B Brunner³

Affiliations

¹ Department of Radiation Oncology, University Medical Centre Freiburg, Germany; CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, UK(1).
² Department of Radiation Oncology, University Medical Centre Freiburg, Germany.
³ Department of Radiation Oncology, University Medical Centre Freiburg, Germany. Electronic address: thomas.brunner@uniklinik-freiburg.de.

PMID: 25497876
DOI: 10.1016/j.radonc.2014.11.043

Abstract

IMRT has been suggested to reduce treatment-related toxicity in pancreatic cancer. We attempted to identify all IMRT-studies indexed in PubMed/Medline, comparing them with recent 3D-CRT trials. The predominant treatment-related toxicities, namely nausea/vomiting, diarrhoea and late GI toxicity, are significantly reduced with IMRT while there was no apparent difference for outcome measures.

Keywords: IMRT; Pancreatic cancer; Radiotherapy planning; Toxicity.

Publication types

Comparative Study
Review
Systematic Review

MeSH terms

Gastrointestinal Diseases / etiology
Hematologic Diseases / etiology
Humans
Nausea / etiology
Pancreatic Neoplasms / radiotherapy*
Radiotherapy, Conformal / adverse effects*
Radiotherapy, Intensity-Modulated / adverse effects
Vomiting / etiology