Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer

Varun Chalivendra; Krishna Latha Kanchi; Michael D Onken; Ashley E Winkler; Elaine Mardis; Ravindra Uppaluri

doi:10.1016/j.gdata.2014.11.006

Genomic analysis to define molecular basis of aggressiveness in a mouse model of oral cancer

Genom Data. 2015 Mar 1:3:61-62. doi: 10.1016/j.gdata.2014.11.006.

Authors

Varun Chalivendra¹, Krishna Latha Kanchi¹, Michael D Onken¹, Ashley E Winkler¹, Elaine Mardis¹, Ravindra Uppaluri¹

Affiliation

¹ Department of Otolaryngology and The Genome Institute, Washington University in Saint Louis School of Medicine, Department of Otolaryngology.

Abstract

To investigate the molecular basis underlying aggressive behavior in oral squamous cell carcinoma (OSCC), our laboratory developed a carcinogen-induced mouse oral cancer (MOC) cell line model that encompasses the growth and metastasis spectrum of its human counterpart. We performed next-generation sequencing (NGS) and gene expression microarray profiles to explore the genomic and transcriptional backgrounds of the differential MOC line phenotypes, as well as, the cross-species relevance of the model. Here we describe the comparative analysis of NGS (www.ncbi.nlm.nih.gov/biosample?LinkName=bioproject_biosample_all&from_uid=247825) and expression microarray (www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE50041) data from the MOC lines and corresponding human data, as described in our recent publication [1].

Abstract

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