Nutrient-sensing mechanisms across evolution

Lynne Chantranupong; Rachel L Wolfson; David M Sabatini

doi:10.1016/j.cell.2015.02.041

Nutrient-sensing mechanisms across evolution

Cell. 2015 Mar 26;161(1):67-83. doi: 10.1016/j.cell.2015.02.041.

Authors

Lynne Chantranupong¹, Rachel L Wolfson¹, David M Sabatini²

Affiliations

¹ Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, 9 Cambridge Center, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
² Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Department of Biology, 9 Cambridge Center, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: sabatini@wi.mit.edu.

Abstract

For organisms to coordinate their growth and development with nutrient availability, they must be able to sense nutrient levels in their environment. Here, we review select nutrient-sensing mechanisms in a few diverse organisms. We discuss how these mechanisms reflect the nutrient requirements of specific species and how they have adapted to the emergence of multicellularity in eukaryotes.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Bacteria / genetics
Bacteria / metabolism*
Biological Evolution
Eukaryota / genetics
Eukaryota / metabolism
Food
Signal Transduction*

Abstract

Publication types

MeSH terms

Grants and funding