The association of an inability to form and maintain close relationships due to a medical condition with anxiety and depressive disorders

J Affect Disord. 2016 Mar 15:193:130-6. doi: 10.1016/j.jad.2015.12.079. Epub 2016 Jan 6.

Abstract

Background: While low social support is a risk factor for mental illness, anxiety and depression's relationship with social impairment specifically resulting from a medical condition is poorly understood. We hypothesize that when a medical illness makes it difficult for people to form and maintain close relationships with others, they will be at increased risk for anxiety and depression.

Methods: Two nationally representative surveys, the National Comorbidity Survey-Replication and National Latino and Asian American Study, included 6805 adults with at least one medical illness and information on social impairment attributed to a medical condition. The Composite International Diagnostic Interview evaluated a 12-month history of anxiety and depressive disorders.

Results: 8.2% of our sample had at least moderate difficulty in forming and maintaining close relationships due to a medical condition. In bivariate analyses, younger age, Latino ethnicity, less education, worse financial status, more chronic illnesses, physical health and discomfort, and problems with mobility, home management, and self-care were associated with this social impairment. In multivariable analyses accounting for possible confounders, there was a dose-dependent relationship between social impairment and the prevalence of anxiety and depression.

Limitations: Data are cross-sectional and our analyses are therefore unable to determine cause-and-effect relationships.

Conclusions: Among adults with one or more medical conditions, social impairment attributed to medical illness was associated with a significantly greater odds of anxiety and depression. Further clarification of this relationship could inform more targeted, personalized interventions to prevent and/or alleviate mental illness in those with chronic medical conditions.

Keywords: Community surveys; Comorbidity; Epidemiology; Social psychiatry; Social support.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anxiety Disorders / epidemiology
  • Anxiety Disorders / psychology*
  • Comorbidity
  • Cross-Sectional Studies
  • Depressive Disorder / epidemiology
  • Depressive Disorder / psychology*
  • Female
  • Humans
  • Interpersonal Relations*
  • Male
  • Middle Aged
  • Prevalence
  • Risk Factors
  • United States / epidemiology
  • Young Adult