Resveratrol supplementation significantly influences obesity measures: a systematic review and dose-response meta-analysis of randomized controlled trials

S M Mousavi; A Milajerdi; A Sheikhi; H Kord-Varkaneh; C Feinle-Bisset; B Larijani; A Esmaillzadeh

doi:10.1111/obr.12775

Resveratrol supplementation significantly influences obesity measures: a systematic review and dose-response meta-analysis of randomized controlled trials

Obes Rev. 2019 Mar;20(3):487-498. doi: 10.1111/obr.12775. Epub 2018 Dec 5.

Authors

S M Mousavi^{1

2}, A Milajerdi^{1

2}, A Sheikhi¹, H Kord-Varkaneh¹, C Feinle-Bisset³, B Larijani⁴, A Esmaillzadeh^{1

5

6}

Affiliations

¹ Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
² Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.
³ University of Adelaide Discipline of Medicine and National Health and Medical Research Council Centre of Research Excellence of Translating Nutritional Science to Good Health, Adelaide, Australia.
⁴ Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
⁵ Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
⁶ Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 30515938
DOI: 10.1111/obr.12775

Abstract

This study aimed to summarize earlier randomized controlled trials on the effects of resveratrol supplementation on body weight (BW), body mass index (BMI), waist circumference (WC) and fat mass (FM). We searched PubMed, SCOPUS, Cochrane Library and Google Scholar from inception to April 2018 using relevant keywords. All clinical trials investigating the effects of resveratrol supplementation on BW, BMI, WC and FM in adults were included. Overall, 28 trials were included. Pooled effect sizes suggested a significant effect of resveratrol administration on weight (weighted mean differences [WMD]: -0.51 kg, 95% confidence interval [CI]: -0.94 to -0.09; I² = 50.3%, P = 0.02), BMI (WMD: -0.17 kg m^-2 , 95% CI: -0.32, -0.03; I² = 49.6%, P = 0.02) and WC (WMD: -0.79 cm, 95% CI: -1.39, -0.2; I² = 13.4%, P = 0.009), respectively. However, no significant effect of resveratrol supplementation on FM was found (WMD: -0.36%, 95% CI: -0.88, 0.15; I² = 0.0%, P = 0.16). Findings from subgroup analysis revealed a significant reduction in BW and BMI in trials using resveratrol at the dosage of <500 mg d^-1 , those with long-term interventions (≥3 month), and performed on people with obesity. Taken together, the data suggest that resveratrol supplementation has beneficial effects to reduce BW, BMI and WC, but not FM.

Keywords: dose-response; meta-analysis; obesity; resveratrol; weight.

Publication types

Meta-Analysis
Systematic Review

MeSH terms

Adiposity / drug effects*
Antioxidants / therapeutic use*
Body Mass Index
Body Weight / drug effects
Dietary Supplements*
Humans
Obesity / diet therapy*
Randomized Controlled Trials as Topic
Resveratrol / therapeutic use*
Treatment Outcome
Waist Circumference / drug effects

Substances

Antioxidants
Resveratrol