The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue: A single centre experience

PLoS One. 2019 Sep 19;14(9):e0222731. doi: 10.1371/journal.pone.0222731. eCollection 2019.

Abstract

Background: Bowel and bladder problems affect more than 50% of people with Multiple Sclerosis (MS). These problems have a large impact on quality of life and place a significant burden on health systems.

Objectives: This study aimed to ascertain the frequency of bladder and bowel problems in a select Australian MS cohort and to investigate the relationships between level of disability, bladder and bowel problems, and fatigue.

Methods: Questionnaires on the nature and severity of MS symptoms were distributed to clients attending an Australian MS centre. Log-binomial regression and multiple linear regression models were used to investigate relationships between disability, fatigue, and bladder and bowel problems.

Results and conclusions: Of 167 questionnaires distributed, 136 were completed. Bladder problems were reported by 87 (74.4%) respondents, whilst 66 (48.9%) experienced functional constipation and 43 (31.9%) faecal incontinence. This frequency in our select Australian MS population is similar to that reported globally. There was a significant correlation between level of disability and: bladder problems (p = 0.015), faecal incontinence (p = 0.001), fatigue (p<0.001) and constipation (p = 0.016, relative risk: 1.16). Further investigation into the causal relationships between various MS symptoms may be beneficial in the development of novel therapeutic strategies for people with MS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Australia
  • Fatigue / complications
  • Fatigue / physiopathology*
  • Fecal Incontinence / etiology
  • Fecal Incontinence / physiopathology
  • Female
  • Humans
  • Intestines / physiopathology*
  • Male
  • Middle Aged
  • Multiple Sclerosis / complications
  • Multiple Sclerosis / physiopathology*
  • Quality of Life
  • Surveys and Questionnaires
  • Urinary Bladder / physiopathology*

Grants and funding

This work was supported by a pilot grant from the National Multiple Sclerosis Society (NMSS), USA and the National Health and Medical Research Council (NHMRC), Australia.PH and TJ are employed by MS Limited. MS Limited provided support in the form of salaries for PH and TJ, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section.