Propensity for seizure-related cortical laminar necrosis in hepatic encephalopathy

James Peters; Nirosen Vijiaratnam; Joseph Z W Wong; Sonia Jitpiriyaroj; Ronil V Chandra; Peter A Kempster

doi:10.1016/j.ebr.2019.100348

Propensity for seizure-related cortical laminar necrosis in hepatic encephalopathy

Epilepsy Behav Rep. 2019 Nov 15:12:100348. doi: 10.1016/j.ebr.2019.100348. eCollection 2019.

Authors

James Peters¹, Nirosen Vijiaratnam¹, Joseph Z W Wong¹, Sonia Jitpiriyaroj¹, Ronil V Chandra^{1

2}, Peter A Kempster^{1

3}

Affiliations

¹ Neurosciences Department, Monash Medical Centre, Clayton, Australia.
² Department of Imaging, Monash Medical Centre, Clayton, Australia.
³ Department of Medicine, School of Clinical Sciences, Monash University, Clayton, Australia.

Abstract

•Hepatic encephalopathy may predispose to seizure-related cortical laminar necrosis.•Elevated ammonia levels potentially compound the excitotoxic effects of epilepsy.•Early identification and treatment of seizures in liver disease could be protective.

Keywords: Cortical laminar necrosis; Epileptogenic zone; Hepatic encephalopathy; Hyperammonaemia; Status epilepticus.