Detour Ahead: Incretin Hormone Signaling Alters Its Intracellular Path as β-Cell Failure Progresses During Diabetes

Front Endocrinol (Lausanne). 2021 Apr 15:12:665345. doi: 10.3389/fendo.2021.665345. eCollection 2021.

Authors

Mehboob A Hussain¹, Erinn Laimon-Thomson¹, Syed M Mustafa², Alexander Deck², Banya Song¹

Affiliations

¹ Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan, Ann Arbor, MI, United States.
² College of Literature, Science and Arts, University of Michigan, Ann Arbor, MI, United States.

No abstract available

Keywords: GPCR coupling; KATP channel; beta cell dysfunction; diabetes; incretin hormone.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Diabetes Mellitus / etiology
Diabetes Mellitus / metabolism
Diabetes Mellitus / pathology*
Disease Progression
Gastric Inhibitory Polypeptide / metabolism*
Humans
Incretins / metabolism*
Insulin-Secreting Cells / metabolism
Insulin-Secreting Cells / pathology*
Receptors, Gastrointestinal Hormone / metabolism*

Substances

Incretins
Receptors, Gastrointestinal Hormone
Gastric Inhibitory Polypeptide
gastric inhibitory polypeptide receptor