Brain ventricles as windows into brain development and disease

Phan Q Duy; Pasko Rakic; Seth L Alper; William E Butler; Christopher A Walsh; Nenad Sestan; Daniel H Geschwind; Sheng Chih Jin; Kristopher T Kahle

doi:10.1016/j.neuron.2021.12.009

Brain ventricles as windows into brain development and disease

Neuron. 2022 Jan 5;110(1):12-15. doi: 10.1016/j.neuron.2021.12.009.

Authors

Phan Q Duy¹, Pasko Rakic², Seth L Alper³, William E Butler⁴, Christopher A Walsh⁵, Nenad Sestan², Daniel H Geschwind⁶, Sheng Chih Jin⁷, Kristopher T Kahle⁸

Affiliations

¹ Department of Neurosurgery, Yale University School of Medicine, New Haven, CT, USA; Medical Scientist Training Program, Yale University School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
² Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA.
³ Division of Nephrology and Vascular Biology Research Center, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, MA, USA.
⁴ Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA.
⁵ Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA; Departments of Pediatrics and Neurology, Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁶ Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
⁷ Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
⁸ Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; MGH Hydrocephalus and Neurodevelopmental Disorders Program, Massachusetts General Hospital, Boston, MA, USA. Electronic address: kahle.kristopher@mgh.harvard.edu.

Abstract

Dilation of the fluid-filled cerebral ventricles (ventriculomegaly) characterizes hydrocephalus and is frequently seen in autism and schizophrenia. Recent work suggests that the genomic study of congenital hydrocephalus may be unexpectedly fertile ground for revealing insights into neural stem cell regulation, human cerebrocortical development, and pathogenesis of neuropsychiatric disease.

Keywords: CH; CSF; NSC; brain ventricle; cerebrospinal fluid; congenital hydrocephalus; genomics; neural development; neural stem cell; neurodevelopmental disorders.

Brain ventricles as windows into brain development and disease

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