Differential roles of insulin receptor in adipocyte progenitor cells in mice

Yexian Yuan; Zuoxiao Shi; Shaolei Xiong; Ruoci Hu; Qing Song; Zhenyuan Song; Sang-Ging Ong; Yuwei Jiang

doi:10.1016/j.mce.2023.111968

Differential roles of insulin receptor in adipocyte progenitor cells in mice

Mol Cell Endocrinol. 2023 Aug 1:573:111968. doi: 10.1016/j.mce.2023.111968. Epub 2023 May 25.

Authors

Yexian Yuan¹, Zuoxiao Shi², Shaolei Xiong³, Ruoci Hu², Qing Song⁴, Zhenyuan Song⁴, Sang-Ging Ong⁵, Yuwei Jiang⁶

Affiliations

¹ Guangdong Laboratory of Lingnan Modern Agriculture, Guangdong Province Key Laboratory of Animal Nutritional Regulation and National Engineering Research Center for Breeding Swine Industry, College of Animal Science, South China Agricultural University, Guangzhou, 510642, China; Department of Physiology and Biophysics, The University of Illinois at Chicago, Chicago, IL, 60612, USA.
² Department of Physiology and Biophysics, The University of Illinois at Chicago, Chicago, IL, 60612, USA; Department of Pharmaceutical Sciences, The University of Illinois at Chicago, Chicago, IL, 60612, USA.
³ Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL 60612, USA.
⁴ Department of Kinesiology and Nutrition, The University of Illinois at Chicago, Chicago, IL, 60612, USA.
⁵ Department of Pharmacology and Regenerative Medicine, College of Medicine, The University of Illinois at Chicago, Illinois, 60612, USA; Division of Cardiology, Department of Medicine, The University of Illinois College of Medicine, Illinois, 60612, USA.
⁶ Department of Physiology and Biophysics, The University of Illinois at Chicago, Chicago, IL, 60612, USA; Department of Pharmaceutical Sciences, The University of Illinois at Chicago, Chicago, IL, 60612, USA; Division of Endocrinology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. Electronic address: yuweij@uic.edu.

Abstract

The development of white adipose tissue (WAT) occurs during distinct embryonic and postnatal stages, and it is subsequently maintained throughout life. However, the specific mediators and mechanisms responsible for WAT development during different phases remain unclear. In this study, we investigate the role of the insulin receptor (IR) in regulating adipogenesis and adipocyte function within adipocyte progenitor cells (APCs) during WAT development and homeostasis. We use two in vivo adipose lineage tracking and deletion systems to delete IR either in embryonic APCs or adult APCs, respectively, to explore the specific requirements of IR during WAT development and WAT homeostasis in mice. Our data suggest that IR expression in APCs may not be essential for adult adipocyte differentiation but appears to be crucial for adipose tissue development. We reveal a surprising divergent role of IR in APCs during WAT development and homeostasis.

Keywords: Adipocyte progenitor cells; Adipose tissue development; Insulin receptor; Lipodystrophy; Tissue homeostasis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adipocytes* / metabolism
Adipogenesis
Adipose Tissue, White / metabolism
Animals
Mice
Obesity / metabolism
Receptor, Insulin* / metabolism
Stem Cells

Substances

Receptor, Insulin

Abstract

Publication types

MeSH terms

Substances

Grants and funding