Improving Outcomes for Infants After Cardiopulmonary Bypass Surgery for Congenital Heart Disease: A Commentary on Recent Randomized Controlled Trials

Luregn J Schlapbach; Kristen S Gibbons; Warwick Butt; Prince J Kannankeril; Jennifer S Li; Kevin D Hill; Nitric Oxide During Cardiopulmonary Bypass to Improve Recovery in Infants With Congenital Heart Defects Follow-Up (NITRIC) Study Group and the Steroids to Reduce Systemic Inflammation after Infant Heart Surgery (STRESS) Network Investigators

doi:10.1097/PCC.0000000000003344

Improving Outcomes for Infants After Cardiopulmonary Bypass Surgery for Congenital Heart Disease: A Commentary on Recent Randomized Controlled Trials

Pediatr Crit Care Med. 2023 Nov 1;24(11):961-965. doi: 10.1097/PCC.0000000000003344. Epub 2023 Aug 21.

Authors

Luregn J Schlapbach^{1

2}, Kristen S Gibbons¹, Warwick Butt^{3

4}, Prince J Kannankeril⁵, Jennifer S Li⁶, Kevin D Hill⁶; Nitric Oxide During Cardiopulmonary Bypass to Improve Recovery in Infants With Congenital Heart Defects Follow-Up (NITRIC) Study Group and the Steroids to Reduce Systemic Inflammation after Infant Heart Surgery (STRESS) Network Investigators

Collaborators

Nitric Oxide During Cardiopulmonary Bypass to Improve Recovery in Infants With Congenital Heart Defects Follow-Up (NITRIC) Study Group and the Steroids to Reduce Systemic Inflammation after Infant Heart Surgery (STRESS) Network Investigators:
Luregn J Schlapbach, Kristen S Gibbons, Stephen B Horton, Kerry Johnson, Debbie A Long, David H F Buckley, Simon Erickson, Marino Festa, Yves d'Udekem, Nelson Alphonso, David S Winlaw, Carmel Delzoppo, Kim van Loon, Mark Jones, Paul J Young, Warwick Butt, Andreas Schibler, Kevin D Hill, Prince J Kannankeril, Jeffrey P Jacobs, H Scott Baldwi, Marshall L Jacobs, Sean M O'Brien, David P Bichel, Eric M Graham, Brian Blasiole, Ashraf Resheidat, Adil S Husain, S Ram Kumar, Jerry L Kirchner, Dianne S Gallup, Joseph W Turek, Mark Bleiweis, Bret Mettler, Alexis Benscoter, Eric Wald, Tara Karamlou, Andrew H Van Bergen, David Overman, Pirooz Eghtesady, Ryan Butts, John S Kim, John P Scott, Brett R Anderson, Michael F Swartz, Patrick I McConnell, David F Vener, Jennifer S Li

Affiliations

¹ Child Health Research Centre, University of Queensland, Brisbane, QL, Australia.
² Department of Intensive Care and Neonatology, and Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
³ Intensive Care Unit, Royal Children's Hospital, Melbourne, VC, Australia.
⁴ Department of Critical Care, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VC, Australia.
⁵ Department of Pediatrics, Center for Pediatric Precision Medicine, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN.
⁶ Division of Pediatric Cardiology, Duke University Medical Center, Durham, NC.

PMID: 37607086
PMCID: PMC10840795 (available on 2024-11-01)
DOI: 10.1097/PCC.0000000000003344

Abstract

The recent NITRIC and STRESS trials demonstrate opportunities to perform pragmatic large randomized trials in congenital heart disease. We discuss lessons learnt from these trials which can inform future trial design and conduct in the field of pediatric heart surgery.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cardiac Surgical Procedures*
Cardiopulmonary Bypass / adverse effects
Heart Defects, Congenital* / surgery
Humans
Infant
Randomized Controlled Trials as Topic

Abstract

Publication types

MeSH terms

Grants and funding