Grevillosides R-S: glucosides of 5-alkylresorcinol derivatives from roots of Ardisia crispa (Thunb.) A. DC

Xing-Xiang Long; Shuang Zhang; Li-Juan Xiang; Rui-Hang Hu; Ting-Ting Feng; Ying Zhou; Xin Yin

doi:10.1080/14786419.2023.2258545

Grevillosides R-S: glucosides of 5-alkylresorcinol derivatives from roots of Ardisia crispa (Thunb.) A. DC

Nat Prod Res. 2023 Sep 15:1-6. doi: 10.1080/14786419.2023.2258545. Online ahead of print.

Authors

Xing-Xiang Long¹, Shuang Zhang¹, Li-Juan Xiang¹, Rui-Hang Hu¹, Ting-Ting Feng¹, Ying Zhou¹, Xin Yin¹

Affiliation

¹ College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, P. R. China.

PMID: 37715301
DOI: 10.1080/14786419.2023.2258545

Abstract

Grevillosides R-S (1-2), two new glucosides of 5-alkylresorcinol derivatives, were isolated from the roots of Ardisia crispa (Thunb.) A. DC. The structures of grevillosides R-S (1-2) were determined by 1D and 2D NMR, HR-MS, UV, IR experiments and by comparison of their spectroscopic and physical data with literature values. In this paper, grevillosides R-S (1-2) were tested for their radical-scavenging activity (DPPH and ABTS) and α-glucosidase inhibitory activity in vitro. Grevillosides R-S (1-2) exhibited weak DPPH radical-scavenging activity with IC₅₀ values of 72.3 and 485.2 μM, respectively. Grevillosides R-S (1-2) exhibited no inhibitory activity against α-glucosidase.

Keywords: 5-alkylresorcinol derivatives; Ardisia crispa (Thunb.) A. DC; Primulaceae; antioxidant activity; α-glucosidase inhibitory activity.