Effect of intrinsic CCK and CCK antagonist on pancreatic growth and pancreatic enzyme secretion in pancreaticobiliary diversion rats

Dig Dis Sci. 1993 Apr;38(4):653-9. doi: 10.1007/BF01316796.

Abstract

When pancreaticobiliary diversion (PBD) surgery was performed in rats, plasma CCK level increased, the pancreas grew mainly by proliferation, and pancreatic trypsinogen showed a remarkable increase, although amylase and lipase synthesis were somewhat decreased. The sensitivity of amylase release against CCK-8 in the pancreatic acini decreased when plasma CCK level was high. These changes in pancreatic growth and pancreatic enzyme secretion caused by PBD were completely inhibited by the CCK-receptor antagonist loxiglumide. From these results, intrinsic CCK was considered to play an important role in both pancreatic enzyme synthesis and proliferation.

Publication types

  • Comparative Study

MeSH terms

  • Amylases / drug effects
  • Amylases / metabolism
  • Animals
  • Biliary Tract Surgical Procedures / methods*
  • Cholecystokinin / antagonists & inhibitors*
  • Cholecystokinin / blood
  • Cholecystokinin / pharmacology*
  • Hypertrophy / chemically induced
  • Hypertrophy / enzymology
  • Lipase / drug effects
  • Lipase / metabolism
  • Male
  • Pancreas / drug effects*
  • Pancreas / enzymology
  • Pancreas / growth & development
  • Pancreas / metabolism
  • Pancreas / pathology
  • Pancreas / surgery*
  • Proglumide / analogs & derivatives*
  • Proglumide / pharmacology
  • Rats
  • Rats, Wistar
  • Secretin / blood
  • Secretin / drug effects
  • Time Factors
  • Trypsinogen / drug effects
  • Trypsinogen / metabolism

Substances

  • Secretin
  • loxiglumide
  • Trypsinogen
  • Cholecystokinin
  • Lipase
  • Amylases
  • Proglumide