Abstract
When pancreaticobiliary diversion (PBD) surgery was performed in rats, plasma CCK level increased, the pancreas grew mainly by proliferation, and pancreatic trypsinogen showed a remarkable increase, although amylase and lipase synthesis were somewhat decreased. The sensitivity of amylase release against CCK-8 in the pancreatic acini decreased when plasma CCK level was high. These changes in pancreatic growth and pancreatic enzyme secretion caused by PBD were completely inhibited by the CCK-receptor antagonist loxiglumide. From these results, intrinsic CCK was considered to play an important role in both pancreatic enzyme synthesis and proliferation.
MeSH terms
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Amylases / drug effects
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Amylases / metabolism
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Animals
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Biliary Tract Surgical Procedures / methods*
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Cholecystokinin / antagonists & inhibitors*
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Cholecystokinin / blood
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Cholecystokinin / pharmacology*
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Hypertrophy / chemically induced
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Hypertrophy / enzymology
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Lipase / drug effects
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Lipase / metabolism
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Male
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Pancreas / drug effects*
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Pancreas / enzymology
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Pancreas / growth & development
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Pancreas / metabolism
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Pancreas / pathology
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Pancreas / surgery*
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Proglumide / analogs & derivatives*
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Proglumide / pharmacology
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Rats
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Rats, Wistar
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Secretin / blood
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Secretin / drug effects
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Time Factors
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Trypsinogen / drug effects
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Trypsinogen / metabolism
Substances
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Secretin
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loxiglumide
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Trypsinogen
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Cholecystokinin
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Lipase
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Amylases
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Proglumide