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Delta-4-androstene-3,17-dione binds androgen receptor, promotes myogenesis in vitro, and increases serum testosterone levels, fat-free mass, and muscle strength in hypogonadal men.
Jasuja R, Ramaraj P, Mac RP, Singh AB, Storer TW, Artaza J, Miller A, Singh R, Taylor WE, Lee ML, Davidson T, Sinha-Hikim I, Gonzalez-Cadavid N, Bhasin S. Jasuja R, et al. J Clin Endocrinol Metab. 2005 Feb;90(2):855-63. doi: 10.1210/jc.2004-1577. Epub 2004 Nov 2. J Clin Endocrinol Metab. 2005. PMID: 15522925
Effects of testosterone replacement in human immunodeficiency virus-infected women with weight loss.
Choi HH, Gray PB, Storer TW, Calof OM, Woodhouse L, Singh AB, Padero C, Mac RP, Sinha-Hikim I, Shen R, Dzekov J, Dzekov C, Kushnir MM, Rockwood AL, Meikle AW, Lee ML, Hays RD, Bhasin S. Choi HH, et al. Among authors: lee ml. J Clin Endocrinol Metab. 2005 Mar;90(3):1531-41. doi: 10.1210/jc.2004-1677. Epub 2004 Dec 21. J Clin Endocrinol Metab. 2005. PMID: 15613414 Clinical Trial.
Pharmacokinetics of a testosterone gel in healthy postmenopausal women.
Singh AB, Lee ML, Sinha-Hikim I, Kushnir M, Meikle W, Rockwood A, Afework S, Bhasin S. Singh AB, et al. Among authors: lee ml. J Clin Endocrinol Metab. 2006 Jan;91(1):136-44. doi: 10.1210/jc.2005-1640. Epub 2005 Nov 1. J Clin Endocrinol Metab. 2006. PMID: 16263817 Clinical Trial.
Effect of nicotine on body composition in mice.
Mangubat M, Lutfy K, Lee ML, Pulido L, Stout D, Davis R, Shin CS, Shahbazian M, Seasholtz S, Sinha-Hikim A, Sinha-Hikim I, O'Dell LE, Lyzlov A, Liu Y, Friedman TC. Mangubat M, et al. Among authors: lee ml. J Endocrinol. 2012 Mar;212(3):317-26. doi: 10.1530/JOE-11-0350. Epub 2011 Dec 2. J Endocrinol. 2012. PMID: 22138237 Free PMC article.
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