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Reduced expression of the insulin receptor in mouse insulinoma (MIN6) cells reveals multiple roles of insulin signaling in gene expression, proliferation, insulin content, and secretion.
Ohsugi M, Cras-Méneur C, Zhou Y, Bernal-Mizrachi E, Johnson JD, Luciani DS, Polonsky KS, Permutt MA. Ohsugi M, et al. Among authors: polonsky ks. J Biol Chem. 2005 Feb 11;280(6):4992-5003. doi: 10.1074/jbc.M411727200. Epub 2004 Nov 15. J Biol Chem. 2005. PMID: 15546857 Free article.
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets.
Johnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS. Johnson JD, et al. Among authors: polonsky ks. J Biol Chem. 2004 Jun 4;279(23):24794-802. doi: 10.1074/jbc.M401216200. Epub 2004 Mar 25. J Biol Chem. 2004. PMID: 15044459 Free article.
Increased islet apoptosis in Pdx1+/- mice.
Johnson JD, Ahmed NT, Luciani DS, Han Z, Tran H, Fujita J, Misler S, Edlund H, Polonsky KS. Johnson JD, et al. Among authors: polonsky ks. J Clin Invest. 2003 Apr;111(8):1147-60. doi: 10.1172/JCI16537. J Clin Invest. 2003. PMID: 12697734 Free PMC article.
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome.
Johnson JD, Bernal-Mizrachi E, Alejandro EU, Han Z, Kalynyak TB, Li H, Beith JL, Gross J, Warnock GL, Townsend RR, Permutt MA, Polonsky KS. Johnson JD, et al. Among authors: polonsky ks. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19575-80. doi: 10.1073/pnas.0604208103. Epub 2006 Dec 8. Proc Natl Acad Sci U S A. 2006. PMID: 17158802 Free PMC article.
286 results