Hynes MJ - Search Results

1

Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis.

Huang EH, Hynes MJ, Zhang T, Ginestier C, Dontu G, Appelman H, Fields JZ, Wicha MS, Boman BM. Huang EH, et al. Among authors: hynes mj. Cancer Res. 2009 Apr 15;69(8):3382-9. doi: 10.1158/0008-5472.CAN-08-4418. Epub 2009 Mar 31. Cancer Res. 2009. PMID: 19336570 Free PMC article.

2

Aldehyde dehydrogenase-expressing colon stem cells contribute to tumorigenesis in the transition from colitis to cancer.

Carpentino JE, Hynes MJ, Appelman HD, Zheng T, Steindler DA, Scott EW, Huang EH. Carpentino JE, et al. Among authors: hynes mj. Cancer Res. 2009 Oct 15;69(20):8208-15. doi: 10.1158/0008-5472.CAN-09-1132. Epub 2009 Oct 6. Cancer Res. 2009. PMID: 19808966 Free PMC article.

3

Review paper: Implications of the "cancer stem cell" hypothesis on murine models of colon cancer and colitis-associated cancer.

Hynes MJ, Huang KM, Huang EH. Hynes MJ, et al. Vet Pathol. 2009 Sep;46(5):819-35. doi: 10.1354/vp.08-VP-0172-H-REV. Epub 2009 May 9. Vet Pathol. 2009. PMID: 19429978 Review.

4

Atorvastatin induces apoptosis in vitro and slows growth of tumor xenografts but not polyp formation in MIN mice.

Huang EH, Johnson LA, Eaton K, Hynes MJ, Carpentino JE, Higgins PD. Huang EH, et al. Among authors: hynes mj. Dig Dis Sci. 2010 Nov;55(11):3086-94. doi: 10.1007/s10620-010-1157-x. Epub 2010 Feb 26. Dig Dis Sci. 2010. PMID: 20186482 Free PMC article.

5

c-Met is a marker of pancreatic cancer stem cells and therapeutic target.

Li C, Wu JJ, Hynes M, Dosch J, Sarkar B, Welling TH, Pasca di Magliano M, Simeone DM. Li C, et al. Gastroenterology. 2011 Dec;141(6):2218-2227.e5. doi: 10.1053/j.gastro.2011.08.009. Epub 2011 Aug 22. Gastroenterology. 2011. PMID: 21864475

6

Anti-DLL4 has broad spectrum activity in pancreatic cancer dependent on targeting DLL4-Notch signaling in both tumor and vasculature cells.

Yen WC, Fischer MM, Hynes M, Wu J, Kim E, Beviglia L, Yeung VP, Song X, Kapoun AM, Lewicki J, Gurney A, Simeone DM, Hoey T. Yen WC, et al. Clin Cancer Res. 2012 Oct 1;18(19):5374-86. doi: 10.1158/1078-0432.CCR-12-0736. Epub 2012 Sep 5. Clin Cancer Res. 2012. PMID: 22952347

7

Novel neutralizing hedgehog antibody MEDI-5304 exhibits antitumor activity by inhibiting paracrine hedgehog signaling.

Michaud NR, Wang Y, McEachern KA, Jordan JJ, Mazzola AM, Hernandez A, Jalla S, Chesebrough JW, Hynes MJ, Belmonte MA, Wang L, Kang JS, Jovanovic J, Laing N, Jenkins DW, Hurt E, Liang M, Frantz C, Hollingsworth RE, Simeone DM, Blakey DC, Bedian V. Michaud NR, et al. Among authors: hynes mj. Mol Cancer Ther. 2014 Feb;13(2):386-98. doi: 10.1158/1535-7163.MCT-13-0420. Epub 2013 Dec 16. Mol Cancer Ther. 2014. PMID: 24344235

8

The Notch pathway is important in maintaining the cancer stem cell population in pancreatic cancer.

Abel EV, Kim EJ, Wu J, Hynes M, Bednar F, Proctor E, Wang L, Dziubinski ML, Simeone DM. Abel EV, et al. PLoS One. 2014 Mar 19;9(3):e91983. doi: 10.1371/journal.pone.0091983. eCollection 2014. PLoS One. 2014. PMID: 24647545 Free PMC article.

9

Carbon Catabolite Repression Governs Diverse Physiological Processes and Development in Aspergillus nidulans.

Chen Y, Dong L, Alam MA, Pardeshi L, Miao Z, Wang F, Tan K, Hynes MJ, Kelly JM, Wong KH. Chen Y, et al. Among authors: hynes mj. mBio. 2021 Feb 22;13(1):e0373421. doi: 10.1128/mbio.03734-21. Epub 2022 Feb 15. mBio. 2021. PMID: 35164551 Free PMC article.

10

Influence of the Chelation Process on the Stability of Organic Trace Mineral Supplements Used in Animal Nutrition.

Byrne L, Hynes MJ, Connolly CD, Murphy RA. Byrne L, et al. Among authors: hynes mj. Animals (Basel). 2021 Jun 10;11(6):1730. doi: 10.3390/ani11061730. Animals (Basel). 2021. PMID: 34200569 Free PMC article.

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