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The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. Zhong L, et al. Among authors: espinosa jm. Cell. 2010 Jan 22;140(2):280-93. doi: 10.1016/j.cell.2009.12.041. Cell. 2010. PMID: 20141841 Free PMC article.
CBX3 regulates efficient RNA processing genome-wide.
Smallwood A, Hon GC, Jin F, Henry RE, Espinosa JM, Ren B. Smallwood A, et al. Among authors: espinosa jm. Genome Res. 2012 Aug;22(8):1426-36. doi: 10.1101/gr.124818.111. Epub 2012 Jun 8. Genome Res. 2012. PMID: 22684280 Free PMC article.
Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.
Linder SJ, Bernasocchi T, Martínez-Pastor B, Sullivan KD, Galbraith MD, Lewis CA, Ferrer CM, Boon R, Silveira GG, Cho HM, Vidoudez C, Shroff S, Oliveira-Costa JP, Ross KN, Massri R, Matoba Y, Kim E, Rueda BR, Stott SL, Gottlieb E, Espinosa JM, Mostoslavsky R. Linder SJ, et al. Among authors: espinosa jm. Nat Metab. 2023 Dec;5(12):2131-2147. doi: 10.1038/s42255-023-00919-3. Epub 2023 Nov 13. Nat Metab. 2023. PMID: 37957387
The p53 circuit board.
Sullivan KD, Gallant-Behm CL, Henry RE, Fraikin JL, Espinosa JM. Sullivan KD, et al. Among authors: espinosa jm. Biochim Biophys Acta. 2012 Apr;1825(2):229-44. doi: 10.1016/j.bbcan.2012.01.004. Epub 2012 Feb 7. Biochim Biophys Acta. 2012. PMID: 22333261 Free PMC article. Review.
ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.
Sullivan KD, Padilla-Just N, Henry RE, Porter CC, Kim J, Tentler JJ, Eckhardt SG, Tan AC, DeGregori J, Espinosa JM. Sullivan KD, et al. Among authors: espinosa jm. Nat Chem Biol. 2012 Jul;8(7):646-54. doi: 10.1038/nchembio.965. Epub 2012 Jun 3. Nat Chem Biol. 2012. PMID: 22660439 Free PMC article.
ΔNp63α represses anti-proliferative genes via H2A.Z deposition.
Gallant-Behm CL, Ramsey MR, Bensard CL, Nojek I, Tran J, Liu M, Ellisen LW, Espinosa JM. Gallant-Behm CL, et al. Among authors: espinosa jm. Genes Dev. 2012 Oct 15;26(20):2325-36. doi: 10.1101/gad.198069.112. Epub 2012 Sep 26. Genes Dev. 2012. PMID: 23019126 Free PMC article.
180 results