Kurumbail RG - Search Results

1

Discovery of potent inhibitors of soluble epoxide hydrolase by combinatorial library design and structure-based virtual screening.

Xing L, McDonald JJ, Kolodziej SA, Kurumbail RG, Williams JM, Warren CJ, O'Neal JM, Skepner JE, Roberds SL. Xing L, et al. Among authors: kurumbail rg. J Med Chem. 2011 Mar 10;54(5):1211-22. doi: 10.1021/jm101382t. Epub 2011 Feb 8. J Med Chem. 2011. PMID: 21302953

2

Synthesis, crystal structure, and activity of pyrazole-based inhibitors of p38 kinase.

Graneto MJ, Kurumbail RG, Vazquez ML, Shieh HS, Pawlitz JL, Williams JM, Stallings WC, Geng L, Naraian AS, Koszyk FJ, Stealey MA, Xu XD, Weier RM, Hanson GJ, Mourey RJ, Compton RP, Mnich SJ, Anderson GD, Monahan JB, Devraj R. Graneto MJ, et al. Among authors: kurumbail rg. J Med Chem. 2007 Nov 15;50(23):5712-9. doi: 10.1021/jm0611915. Epub 2007 Oct 19. J Med Chem. 2007. PMID: 17948975

3

Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.

Xing L, Shieh HS, Selness SR, Devraj RV, Walker JK, Devadas B, Hope HR, Compton RP, Schindler JF, Hirsch JL, Benson AG, Kurumbail RG, Stegeman RA, Williams JM, Broadus RM, Walden Z, Monahan JB. Xing L, et al. Among authors: kurumbail rg. Biochemistry. 2009 Jul 14;48(27):6402-11. doi: 10.1021/bi900655f. Biochemistry. 2009. PMID: 19496616

4

Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase.

Selness SR, Devraj RV, Monahan JB, Boehm TL, Walker JK, Devadas B, Durley RC, Kurumbail R, Shieh H, Xing L, Hepperle M, Rucker PV, Jerome KD, Benson AG, Marrufo LD, Madsen HM, Hitchcock J, Owen TJ, Christie L, Promo MA, Hickory BS, Alvira E, Naing W, Blevis-Bal R. Selness SR, et al. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5851-6. doi: 10.1016/j.bmcl.2009.08.082. Epub 2009 Aug 27. Bioorg Med Chem Lett. 2009. PMID: 19751974

5

Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase.

Selness SR, Boehm TL, Walker JK, Devadas B, Durley RC, Kurumbail R, Shieh H, Xing L, Hepperle M, Rucker PV, Jerome KD, Benson AG, Marrufo LD, Madsen HM, Hitchcock J, Owen TJ, Christie L, Promo MA, Hickory BS, Alvira E, Naing W, Blevis-Bal R, Devraj RV, Messing D, Schindler JF, Hirsch J, Saabye M, Bonar S, Webb E, Anderson G, Monahan JB. Selness SR, et al. Bioorg Med Chem Lett. 2011 Jul 1;21(13):4059-65. doi: 10.1016/j.bmcl.2011.04.120. Epub 2011 May 13. Bioorg Med Chem Lett. 2011. PMID: 21640588

6

Covalent inhibitors of interleukin-2 inducible T cell kinase (itk) with nanomolar potency in a whole-blood assay.

Zapf CW, Gerstenberger BS, Xing L, Limburg DC, Anderson DR, Caspers N, Han S, Aulabaugh A, Kurumbail R, Shakya S, Li X, Spaulding V, Czerwinski RM, Seth N, Medley QG. Zapf CW, et al. J Med Chem. 2012 Nov 26;55(22):10047-63. doi: 10.1021/jm301190s. Epub 2012 Nov 12. J Med Chem. 2012. PMID: 23098091

7

Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions.

Xing L, Kurumbail RG, Frazier RB, Davies MS, Fujiwara H, Weinberg RA, Gierse JK, Caspers N, Carter JS, McDonald JJ, Moore WM, Vazquez ML. Xing L, et al. Among authors: kurumbail rg. J Comput Aided Mol Des. 2009 Jan;23(1):13-24. doi: 10.1007/s10822-008-9233-4. Epub 2008 Sep 6. J Comput Aided Mol Des. 2009. PMID: 18777160

8

Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors.

Parlow JJ, Dice TA, Lachance RM, Girard TJ, Stevens AM, Stegeman RA, Stallings WC, Kurumbail RG, South MS. Parlow JJ, et al. Among authors: kurumbail rg. J Med Chem. 2003 Sep 11;46(19):4043-9. doi: 10.1021/jm030130t. J Med Chem. 2003. PMID: 12954057

9

Design, synthesis, and crystal structure of selective 2-pyridone tissue factor VIIa inhibitors.

Parlow JJ, Kurumbail RG, Stegeman RA, Stevens AM, Stallings WC, South MS. Parlow JJ, et al. Among authors: kurumbail rg. J Med Chem. 2003 Oct 23;46(22):4696-701. doi: 10.1021/jm0301686. J Med Chem. 2003. PMID: 14561089

10

Benzothiophene inhibitors of MK2. Part 1: structure-activity relationships, assessments of selectivity and cellular potency.

Anderson DR, Meyers MJ, Kurumbail RG, Caspers N, Poda GI, Long SA, Pierce BS, Mahoney MW, Mourey RJ. Anderson DR, et al. Among authors: kurumbail rg. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4878-81. doi: 10.1016/j.bmcl.2009.02.015. Epub 2009 Feb 8. Bioorg Med Chem Lett. 2009. PMID: 19616945

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