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Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.
Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. Guevara-Aguirre J, et al. Among authors: balasubramanian p. Sci Transl Med. 2011 Feb 16;3(70):70ra13. doi: 10.1126/scitranslmed.3001845. Sci Transl Med. 2011. PMID: 21325617 Free PMC article.
Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.
Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD. Levine ME, et al. Among authors: balasubramanian p. Cell Metab. 2014 Mar 4;19(3):407-17. doi: 10.1016/j.cmet.2014.02.006. Cell Metab. 2014. PMID: 24606898 Free PMC article.
Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans.
Nashiro K, Guevara-Aguirre J, Braskie MN, Hafzalla GW, Velasco R, Balasubramanian P, Wei M, Thompson PM, Mather M, Nelson MD, Guevara A, Teran E, Longo VD. Nashiro K, et al. Among authors: balasubramanian p. J Neurosci. 2017 Feb 15;37(7):1696-1707. doi: 10.1523/JNEUROSCI.1929-16.2016. Epub 2017 Jan 10. J Neurosci. 2017. PMID: 28073935 Free PMC article.
GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity.
Guevara-Aguirre J, Rosenbloom AL, Balasubramanian P, Teran E, Guevara-Aguirre M, Guevara C, Procel P, Alfaras I, De Cabo R, Di Biase S, Narvaez L, Saavedra J, Longo VD. Guevara-Aguirre J, et al. Among authors: balasubramanian p. J Clin Endocrinol Metab. 2015 Jul;100(7):2589-96. doi: 10.1210/jc.2015-1678. Epub 2015 May 18. J Clin Endocrinol Metab. 2015. PMID: 25985182 Free PMC article.
Growth factors, aging and age-related diseases.
Balasubramanian P, Longo VD. Balasubramanian P, et al. Growth Horm IGF Res. 2016 Jun;28:66-8. doi: 10.1016/j.ghir.2016.01.001. Epub 2016 Jan 7. Growth Horm IGF Res. 2016. PMID: 26883276 Free PMC article.
Linking Klotho, Nrf2, MAP kinases and aging.
Balasubramanian P, Longo VD. Balasubramanian P, et al. Aging (Albany NY). 2010 Oct;2(10):632-3. doi: 10.18632/aging.100219. Aging (Albany NY). 2010. PMID: 21076180 Free PMC article. No abstract available.
439 results