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Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans.
Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. Guevara-Aguirre J, et al. Among authors: de cabo r. Sci Transl Med. 2011 Feb 16;3(70):70ra13. doi: 10.1126/scitranslmed.3001845. Sci Transl Med. 2011. PMID: 21325617 Free PMC article.
NRF2, cancer and calorie restriction.
Martín-Montalvo A, Villalba JM, Navas P, de Cabo R. Martín-Montalvo A, et al. Among authors: de cabo r. Oncogene. 2011 Feb 3;30(5):505-20. doi: 10.1038/onc.2010.492. Epub 2010 Nov 8. Oncogene. 2011. PMID: 21057541 Free PMC article. Review.
Mitochondrial metabolic reprogramming induced by calorie restriction.
Martin-Montalvo A, de Cabo R. Martin-Montalvo A, et al. Among authors: de cabo r. Antioxid Redox Signal. 2013 Jul 20;19(3):310-20. doi: 10.1089/ars.2012.4866. Epub 2012 Oct 15. Antioxid Redox Signal. 2013. PMID: 22901095 Free PMC article. Review.
Interventions to Slow Aging in Humans: Are We Ready?
Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L. Longo VD, et al. Among authors: de cabo r. Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. Aging Cell. 2015. PMID: 25902704 Free PMC article. Review.
GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity.
Guevara-Aguirre J, Rosenbloom AL, Balasubramanian P, Teran E, Guevara-Aguirre M, Guevara C, Procel P, Alfaras I, De Cabo R, Di Biase S, Narvaez L, Saavedra J, Longo VD. Guevara-Aguirre J, et al. Among authors: de cabo r. J Clin Endocrinol Metab. 2015 Jul;100(7):2589-96. doi: 10.1210/jc.2015-1678. Epub 2015 May 18. J Clin Endocrinol Metab. 2015. PMID: 25985182 Free PMC article.
Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity.
Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan TE, Longo VD. Di Biase S, et al. Among authors: de cabo r. Cancer Cell. 2016 Jul 11;30(1):136-146. doi: 10.1016/j.ccell.2016.06.005. Cancer Cell. 2016. PMID: 27411588 Free PMC article.
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast.
Jiménez-Hidalgo M, Santos-Ocaña C, Padilla S, Villalba JM, López-Lluch G, Martín-Montalvo A, Minor RK, Sinclair DA, de Cabo R, Navas P. Jiménez-Hidalgo M, et al. Among authors: de cabo r. Aging Cell. 2009 Apr;8(2):140-51. doi: 10.1111/j.1474-9726.2009.00461.x. Epub 2009 Feb 23. Aging Cell. 2009. PMID: 19239415 Free PMC article.
369 results