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Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin.
Muili KA, Wang D, Orabi AI, Sarwar S, Luo Y, Javed TA, Eisses JF, Mahmood SM, Jin S, Singh VP, Ananthanaravanan M, Perides G, Williams JA, Molkentin JD, Husain SZ. Muili KA, et al. Among authors: luo y. J Biol Chem. 2013 Jan 4;288(1):570-80. doi: 10.1074/jbc.M112.428896. Epub 2012 Nov 12. J Biol Chem. 2013. PMID: 23148215 Free PMC article.
Ryanodine receptors contribute to bile acid-induced pathological calcium signaling and pancreatitis in mice.
Husain SZ, Orabi AI, Muili KA, Luo Y, Sarwar S, Mahmood SM, Wang D, Choo-Wing R, Singh VP, Parness J, Ananthanaravanan M, Bhandari V, Perides G. Husain SZ, et al. Among authors: luo y. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15;302(12):G1423-33. doi: 10.1152/ajpgi.00546.2011. Epub 2012 Apr 19. Am J Physiol Gastrointest Liver Physiol. 2012. PMID: 22517774 Free PMC article.
IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules.
Orabi AI, Luo Y, Ahmad MU, Shah AU, Mannan Z, Wang D, Sarwar S, Muili KA, Shugrue C, Kolodecik TR, Singh VP, Lowe ME, Thrower E, Chen J, Husain SZ. Orabi AI, et al. Among authors: luo y. PLoS One. 2012;7(11):e48465. doi: 10.1371/journal.pone.0048465. Epub 2012 Nov 21. PLoS One. 2012. PMID: 23185258 Free PMC article.
Bile acid sequestration reverses liver injury and prevents progression of nonalcoholic steatohepatitis in Western diet-fed mice.
Takahashi S, Luo Y, Ranjit S, Xie C, Libby AE, Orlicky DJ, Dvornikov A, Wang XX, Myakala K, Jones BA, Bhasin K, Wang D, McManaman JL, Krausz KW, Gratton E, Ir D, Robertson CE, Frank DN, Gonzalez FJ, Levi M. Takahashi S, et al. Among authors: luo y. J Biol Chem. 2020 Apr 3;295(14):4733-4747. doi: 10.1074/jbc.RA119.011913. Epub 2020 Feb 19. J Biol Chem. 2020. PMID: 32075905 Free PMC article.
SGLT2 Protein Expression Is Increased in Human Diabetic Nephropathy: SGLT2 PROTEIN INHIBITION DECREASES RENAL LIPID ACCUMULATION, INFLAMMATION, AND THE DEVELOPMENT OF NEPHROPATHY IN DIABETIC MICE.
Wang XX, Levi J, Luo Y, Myakala K, Herman-Edelstein M, Qiu L, Wang D, Peng Y, Grenz A, Lucia S, Dobrinskikh E, D'Agati VD, Koepsell H, Kopp JB, Rosenberg AZ, Levi M. Wang XX, et al. Among authors: luo y. J Biol Chem. 2017 Mar 31;292(13):5335-5348. doi: 10.1074/jbc.M117.779520. Epub 2017 Feb 14. J Biol Chem. 2017. PMID: 28196866 Free PMC article.
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