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Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin.
Muili KA, Wang D, Orabi AI, Sarwar S, Luo Y, Javed TA, Eisses JF, Mahmood SM, Jin S, Singh VP, Ananthanaravanan M, Perides G, Williams JA, Molkentin JD, Husain SZ. Muili KA, et al. Among authors: sarwar s. J Biol Chem. 2013 Jan 4;288(1):570-80. doi: 10.1074/jbc.M112.428896. Epub 2012 Nov 12. J Biol Chem. 2013. PMID: 23148215 Free PMC article.
Ryanodine receptors contribute to bile acid-induced pathological calcium signaling and pancreatitis in mice.
Husain SZ, Orabi AI, Muili KA, Luo Y, Sarwar S, Mahmood SM, Wang D, Choo-Wing R, Singh VP, Parness J, Ananthanaravanan M, Bhandari V, Perides G. Husain SZ, et al. Among authors: sarwar s. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15;302(12):G1423-33. doi: 10.1152/ajpgi.00546.2011. Epub 2012 Apr 19. Am J Physiol Gastrointest Liver Physiol. 2012. PMID: 22517774 Free PMC article.
IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules.
Orabi AI, Luo Y, Ahmad MU, Shah AU, Mannan Z, Wang D, Sarwar S, Muili KA, Shugrue C, Kolodecik TR, Singh VP, Lowe ME, Thrower E, Chen J, Husain SZ. Orabi AI, et al. Among authors: sarwar s. PLoS One. 2012;7(11):e48465. doi: 10.1371/journal.pone.0048465. Epub 2012 Nov 21. PLoS One. 2012. PMID: 23185258 Free PMC article.
Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs.
Eisses JF, Criscimanna A, Dionise ZR, Orabi AI, Javed TA, Sarwar S, Jin S, Zhou L, Singh S, Poddar M, Davis AW, Tosun AB, Ozolek JA, Lowe ME, Monga SP, Rohde GK, Esni F, Husain SZ. Eisses JF, et al. Among authors: sarwar s. Am J Pathol. 2015 Dec;185(12):3304-15. doi: 10.1016/j.ajpath.2015.08.006. Epub 2015 Oct 23. Am J Pathol. 2015. PMID: 26476347 Free PMC article.
381 results