Miyata Y - Search Results

1

Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.

Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Miyata Y, et al. ACS Chem Neurosci. 2013 Jun 19;4(6):930-9. doi: 10.1021/cn300210g. Epub 2013 Mar 20. ACS Chem Neurosci. 2013. PMID: 23472668 Free PMC article.

2

Pharmacological targeting of the Hsp70 chaperone.

Patury S, Miyata Y, Gestwicki JE. Patury S, et al. Among authors: miyata y. Curr Top Med Chem. 2009;9(15):1337-51. doi: 10.2174/156802609789895674. Curr Top Med Chem. 2009. PMID: 19860737 Free PMC article. Review.

3

Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones.

Rousaki A, Miyata Y, Jinwal UK, Dickey CA, Gestwicki JE, Zuiderweg ER. Rousaki A, et al. Among authors: miyata y. J Mol Biol. 2011 Aug 19;411(3):614-32. doi: 10.1016/j.jmb.2011.06.003. Epub 2011 Jun 25. J Mol Biol. 2011. PMID: 21708173 Free PMC article.

4

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.

Miyata Y, Koren J, Kiray J, Dickey CA, Gestwicki JE. Miyata Y, et al. Future Med Chem. 2011 Sep;3(12):1523-37. doi: 10.4155/fmc.11.88. Future Med Chem. 2011. PMID: 21882945 Free PMC article. Review.

5

Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70.

Miyata Y, Rauch JN, Jinwal UK, Thompson AD, Srinivasan S, Dickey CA, Gestwicki JE. Miyata Y, et al. Chem Biol. 2012 Nov 21;19(11):1391-9. doi: 10.1016/j.chembiol.2012.07.026. Chem Biol. 2012. PMID: 23177194 Free PMC article.

6

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation.

Wang AM, Miyata Y, Klinedinst S, Peng HM, Chua JP, Komiyama T, Li X, Morishima Y, Merry DE, Pratt WB, Osawa Y, Collins CA, Gestwicki JE, Lieberman AP. Wang AM, et al. Among authors: miyata y. Nat Chem Biol. 2013 Feb;9(2):112-8. doi: 10.1038/nchembio.1140. Epub 2012 Dec 9. Nat Chem Biol. 2013. PMID: 23222885 Free PMC article.

7

Chemical manipulation of hsp70 ATPase activity regulates tau stability.

Jinwal UK, Miyata Y, Koren J 3rd, Jones JR, Trotter JH, Chang L, O'Leary J, Morgan D, Lee DC, Shults CL, Rousaki A, Weeber EJ, Zuiderweg ER, Gestwicki JE, Dickey CA. Jinwal UK, et al. Among authors: miyata y. J Neurosci. 2009 Sep 30;29(39):12079-88. doi: 10.1523/JNEUROSCI.3345-09.2009. J Neurosci. 2009. PMID: 19793966 Free PMC article.

8

High-throughput screen for Escherichia coli heat shock protein 70 (Hsp70/DnaK): ATPase assay in low volume by exploiting energy transfer.

Miyata Y, Chang L, Bainor A, McQuade TJ, Walczak CP, Zhang Y, Larsen MJ, Kirchhoff P, Gestwicki JE. Miyata Y, et al. J Biomol Screen. 2010 Dec;15(10):1211-9. doi: 10.1177/1087057110380571. Epub 2010 Oct 6. J Biomol Screen. 2010. PMID: 20926844 Free PMC article.

9

Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance.

Koren J 3rd, Miyata Y, Kiray J, O'Leary JC 3rd, Nguyen L, Guo J, Blair LJ, Li X, Jinwal UK, Cheng JQ, Gestwicki JE, Dickey CA. Koren J 3rd, et al. Among authors: miyata y. PLoS One. 2012;7(4):e35566. doi: 10.1371/journal.pone.0035566. Epub 2012 Apr 26. PLoS One. 2012. PMID: 22563386 Free PMC article.

10

Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.

Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, Young ZT, Atkins CA, Zhang B, Lawson LY, Weeber EJ, Brodsky JL, Gestwicki JE, Dickey CA. Abisambra J, et al. Among authors: miyata y. Biol Psychiatry. 2013 Sep 1;74(5):367-74. doi: 10.1016/j.biopsych.2013.02.027. Epub 2013 Apr 19. Biol Psychiatry. 2013. PMID: 23607970 Free PMC article.

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