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Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.
Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Miyata Y, et al. Among authors: sun d. ACS Chem Neurosci. 2013 Jun 19;4(6):930-9. doi: 10.1021/cn300210g. Epub 2013 Mar 20. ACS Chem Neurosci. 2013. PMID: 23472668 Free PMC article.
Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS.
Zwicker JD, Smith D, Guerra AJ, Hitchens JR, Haug N, Vander Roest S, Lee P, Wen B, Sun D, Wang L, Keep RF, Xiang J, Carruthers VB, Larsen SD. Zwicker JD, et al. Among authors: sun d. ACS Chem Neurosci. 2020 Aug 19;11(16):2450-2463. doi: 10.1021/acschemneuro.9b00674. Epub 2020 Feb 18. ACS Chem Neurosci. 2020. PMID: 32027110 Free PMC article.
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