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Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo.
Shirude PS, Shandil R, Sadler C, Naik M, Hosagrahara V, Hameed S, Shinde V, Bathula C, Humnabadkar V, Kumar N, Reddy J, Panduga V, Sharma S, Ambady A, Hegde N, Whiteaker J, McLaughlin RE, Gardner H, Madhavapeddi P, Ramachandran V, Kaur P, Narayan A, Guptha S, Awasthy D, Narayan C, Mahadevaswamy J, Vishwas KG, Ahuja V, Srivastava A, Prabhakar KR, Bharath S, Kale R, Ramaiah M, Choudhury NR, Sambandamurthy VK, Solapure S, Iyer PS, Narayanan S, Chatterji M. Shirude PS, et al. Among authors: ahuja v. J Med Chem. 2013 Dec 12;56(23):9701-8. doi: 10.1021/jm401382v. Epub 2013 Nov 21. J Med Chem. 2013. PMID: 24215368
Thiazolopyridine ureas as novel antitubercular agents acting through inhibition of DNA Gyrase B.
Kale MG, Raichurkar A, P SH, Waterson D, McKinney D, Manjunatha MR, Kranthi U, Koushik K, Jena Lk, Shinde V, Rudrapatna S, Barde S, Humnabadkar V, Madhavapeddi P, Basavarajappa H, Ghosh A, Ramya VK, Guptha S, Sharma S, Vachaspati P, Kumar KN, Giridhar J, Reddy J, Panduga V, Ganguly S, Ahuja V, Gaonkar S, Kumar CN, Ogg D, Tucker JA, Boriack-Sjodin PA, de Sousa SM, Sambandamurthy VK, Ghorpade SR. Kale MG, et al. Among authors: ahuja v. J Med Chem. 2013 Nov 14;56(21):8834-48. doi: 10.1021/jm401268f. Epub 2013 Oct 18. J Med Chem. 2013. PMID: 24088190
Thiazolopyridone ureas as DNA gyrase B inhibitors: optimization of antitubercular activity and efficacy.
Kale RR, Kale MG, Waterson D, Raichurkar A, Hameed SP, Manjunatha MR, Kishore Reddy BK, Malolanarasimhan K, Shinde V, Koushik K, Jena LK, Menasinakai S, Humnabadkar V, Madhavapeddi P, Basavarajappa H, Sharma S, Nandishaiah R, Mahesh Kumar KN, Ganguly S, Ahuja V, Gaonkar S, Naveen Kumar CN, Ogg D, Boriack-Sjodin PA, Sambandamurthy VK, de Sousa SM, Ghorpade SR. Kale RR, et al. Among authors: ahuja v. Bioorg Med Chem Lett. 2014 Feb 1;24(3):870-9. doi: 10.1016/j.bmcl.2013.12.080. Epub 2013 Dec 25. Bioorg Med Chem Lett. 2014. PMID: 24405701
In vitro and in vivo efficacy of β-lactams against replicating and slowly growing/nonreplicating Mycobacterium tuberculosis.
Solapure S, Dinesh N, Shandil R, Ramachandran V, Sharma S, Bhattacharjee D, Ganguly S, Reddy J, Ahuja V, Panduga V, Parab M, Vishwas KG, Kumar N, Balganesh M, Balasubramanian V. Solapure S, et al. Among authors: ahuja v. Antimicrob Agents Chemother. 2013 Jun;57(6):2506-10. doi: 10.1128/AAC.00023-13. Epub 2013 Mar 18. Antimicrob Agents Chemother. 2013. PMID: 23507276 Free PMC article.
Effect of repeated dosing on rifampin exposure in BALB/c mice.
Hosagrahara V, Reddy J, Ganguly S, Panduga V, Ahuja V, Parab M, Giridhar J. Hosagrahara V, et al. Among authors: ahuja v. Eur J Pharm Sci. 2013 Apr 11;49(1):33-8. doi: 10.1016/j.ejps.2013.01.017. Epub 2013 Feb 8. Eur J Pharm Sci. 2013. PMID: 23395915
A multi-targeting pre-clinical candidate against drug-resistant tuberculosis.
Kaur P, Potluri V, Ahuja VK, Naveenkumar CN, Krishnamurthy RV, Gangadharaiah ST, Shivarudraiah P, Eswaran S, Nirmal CR, Mahizhaveni B, Dusthackeer A, Mondal R, Batt SM, Richardson EJ, Loman NJ, Besra GS, Shandil RK, Narayanan S. Kaur P, et al. Among authors: ahuja vk. Tuberculosis (Edinb). 2021 Jul;129:102104. doi: 10.1016/j.tube.2021.102104. Epub 2021 Jun 18. Tuberculosis (Edinb). 2021. PMID: 34214859
Development and validation of LC/MS/MS method for Triciribine and its monophosphate metabolite in plasma and RBC: Application to mice pharmacokinetic studies.
Narayanan S, Shandil RK, Ahuja VK, Shanmugam SS, Mahesh K U H, Ramesh N, Surendran N. Narayanan S, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jun 1;1174:122714. doi: 10.1016/j.jchromb.2021.122714. Epub 2021 Apr 20. J Chromatogr B Analyt Technol Biomed Life Sci. 2021. PMID: 33962189
656 results