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Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill Mycobacterium tuberculosis and are efficacious in vivo.
Shirude PS, Shandil R, Sadler C, Naik M, Hosagrahara V, Hameed S, Shinde V, Bathula C, Humnabadkar V, Kumar N, Reddy J, Panduga V, Sharma S, Ambady A, Hegde N, Whiteaker J, McLaughlin RE, Gardner H, Madhavapeddi P, Ramachandran V, Kaur P, Narayan A, Guptha S, Awasthy D, Narayan C, Mahadevaswamy J, Vishwas KG, Ahuja V, Srivastava A, Prabhakar KR, Bharath S, Kale R, Ramaiah M, Choudhury NR, Sambandamurthy VK, Solapure S, Iyer PS, Narayanan S, Chatterji M. Shirude PS, et al. Among authors: kumar n. J Med Chem. 2013 Dec 12;56(23):9701-8. doi: 10.1021/jm401382v. Epub 2013 Nov 21. J Med Chem. 2013. PMID: 24215368
1,4-azaindole, a potential drug candidate for treatment of tuberculosis.
Chatterji M, Shandil R, Manjunatha MR, Solapure S, Ramachandran V, Kumar N, Saralaya R, Panduga V, Reddy J, Prabhakar KR, Sharma S, Sadler C, Cooper CB, Mdluli K, Iyer PS, Narayanan S, Shirude PS. Chatterji M, et al. Among authors: kumar n. Antimicrob Agents Chemother. 2014 Sep;58(9):5325-31. doi: 10.1128/AAC.03233-14. Epub 2014 Jun 23. Antimicrob Agents Chemother. 2014. PMID: 24957839 Free PMC article.
Scaffold Morphing To Identify Novel DprE1 Inhibitors with Antimycobacterial Activity.
R MM, Shandil R, Panda M, Sadler C, Ambady A, Panduga V, Kumar N, Mahadevaswamy J, Sreenivasaiah M, Narayan A, Guptha S, Sharma S, Sambandamurthy VK, Ramachandran V, Mallya M, Cooper C, Mdluli K, Butler S, Tommasi R, Iyer PS, Narayanan S, Chatterji M, Shirude PS. R MM, et al. Among authors: kumar n. ACS Med Chem Lett. 2019 Sep 23;10(10):1480-1485. doi: 10.1021/acsmedchemlett.9b00343. eCollection 2019 Oct 10. ACS Med Chem Lett. 2019. PMID: 31620237 Free PMC article.
Effect of coadministration of moxifloxacin and rifampin on Mycobacterium tuberculosis in a murine aerosol infection model.
Balasubramanian V, Solapure S, Gaonkar S, Mahesh Kumar KN, Shandil RK, Deshpande A, Kumar N, Vishwas KG, Panduga V, Reddy J, Ganguly S, Louie A, Drusano GL. Balasubramanian V, et al. Among authors: kumar n. Antimicrob Agents Chemother. 2012 Jun;56(6):3054-7. doi: 10.1128/AAC.06383-11. Epub 2012 Apr 2. Antimicrob Agents Chemother. 2012. PMID: 22470118 Free PMC article.
In vitro and in vivo efficacy of β-lactams against replicating and slowly growing/nonreplicating Mycobacterium tuberculosis.
Solapure S, Dinesh N, Shandil R, Ramachandran V, Sharma S, Bhattacharjee D, Ganguly S, Reddy J, Ahuja V, Panduga V, Parab M, Vishwas KG, Kumar N, Balganesh M, Balasubramanian V. Solapure S, et al. Among authors: kumar n. Antimicrob Agents Chemother. 2013 Jun;57(6):2506-10. doi: 10.1128/AAC.00023-13. Epub 2013 Mar 18. Antimicrob Agents Chemother. 2013. PMID: 23507276 Free PMC article.
Assessment of Mycobacterium tuberculosis pantothenate kinase vulnerability through target knockdown and mechanistically diverse inhibitors.
Reddy BK, Landge S, Ravishankar S, Patil V, Shinde V, Tantry S, Kale M, Raichurkar A, Menasinakai S, Mudugal NV, Ambady A, Ghosh A, Tunduguru R, Kaur P, Singh R, Kumar N, Bharath S, Sundaram A, Bhat J, Sambandamurthy VK, Björkelid C, Jones TA, Das K, Bandodkar B, Malolanarasimhan K, Mukherjee K, Ramachandran V. Reddy BK, et al. Among authors: kumar n. Antimicrob Agents Chemother. 2014 Jun;58(6):3312-26. doi: 10.1128/AAC.00140-14. Epub 2014 Mar 31. Antimicrob Agents Chemother. 2014. PMID: 24687493 Free PMC article.
In silico-based high-throughput screen for discovery of novel combinations for tuberculosis treatment.
Singh R, Ramachandran V, Shandil R, Sharma S, Khandelwal S, Karmarkar M, Kumar N, Solapure S, Saralaya R, Nanduri R, Panduga V, Reddy J, Prabhakar KR, Rajagopalan S, Rao N, Narayanan S, Anandkumar A, Balasubramanian V, Datta S. Singh R, et al. Among authors: kumar n. Antimicrob Agents Chemother. 2015 Sep;59(9):5664-74. doi: 10.1128/AAC.05148-14. Epub 2015 Jul 6. Antimicrob Agents Chemother. 2015. PMID: 26149995 Free PMC article.
Aerosol infection model of tuberculosis in wistar rats.
Gaonkar S, Bharath S, Kumar N, Balasubramanian V, Shandil RK. Gaonkar S, et al. Among authors: kumar n. Int J Microbiol. 2010;2010:426035. doi: 10.1155/2010/426035. Epub 2010 Mar 18. Int J Microbiol. 2010. PMID: 20339504 Free PMC article.
8,844 results