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Forcefield_NCAA: ab initio charge parameters to aid in the discovery and design of therapeutic proteins and peptides with unnatural amino acids and their application to complement inhibitors of the compstatin family.
Khoury GA, Smadbeck J, Tamamis P, Vandris AC, Kieslich CA, Floudas CA. Khoury GA, et al. Among authors: smadbeck j. ACS Synth Biol. 2014 Dec 19;3(12):855-69. doi: 10.1021/sb400168u. Epub 2014 Jan 14. ACS Synth Biol. 2014. PMID: 24932669 Free PMC article.
New compstatin peptides containing N-terminal extensions and non-natural amino acids exhibit potent complement inhibition and improved solubility characteristics.
Gorham RD Jr, Forest DL, Khoury GA, Smadbeck J, Beecher CN, Healy ED, Tamamis P, Archontis G, Larive CK, Floudas CA, Radeke MJ, Johnson LV, Morikis D. Gorham RD Jr, et al. Among authors: smadbeck j. J Med Chem. 2015 Jan 22;58(2):814-26. doi: 10.1021/jm501345y. Epub 2014 Dec 29. J Med Chem. 2015. PMID: 25494040 Free PMC article.
79 results