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Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM. Wang S, et al. Among authors: sabatini dm, sabatini bl. Science. 2015 Jan 9;347(6218):188-94. doi: 10.1126/science.1257132. Epub 2015 Jan 7. Science. 2015. PMID: 25567906 Free PMC article.
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM. Sancak Y, et al. Among authors: sabatini dm. Mol Cell. 2007 Mar 23;25(6):903-15. doi: 10.1016/j.molcel.2007.03.003. Mol Cell. 2007. PMID: 17386266 Free article.
Increased mTORC1 signaling UPRegulates stress.
Reiling JH, Sabatini DM. Reiling JH, et al. Among authors: sabatini dm. Mol Cell. 2008 Mar 14;29(5):533-5. doi: 10.1016/j.molcel.2008.02.011. Mol Cell. 2008. PMID: 18342598 Free article.
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM. Sancak Y, et al. Among authors: sabatini dm. Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22. Science. 2008. PMID: 18497260 Free PMC article.
Rag proteins regulate amino-acid-induced mTORC1 signalling.
Sancak Y, Sabatini DM. Sancak Y, et al. Among authors: sabatini dm. Biochem Soc Trans. 2009 Feb;37(Pt 1):289-90. doi: 10.1042/BST0370289. Biochem Soc Trans. 2009. PMID: 19143648 Free PMC article. Review.
Rapamycin inhibits mTORC1, but not completely.
Thoreen CC, Sabatini DM. Thoreen CC, et al. Among authors: sabatini dm. Autophagy. 2009 Jul;5(5):725-6. doi: 10.4161/auto.5.5.8504. Epub 2009 Jul 22. Autophagy. 2009. PMID: 19395872
mTOR signaling at a glance.
Laplante M, Sabatini DM. Laplante M, et al. Among authors: sabatini dm. J Cell Sci. 2009 Oct 15;122(Pt 20):3589-94. doi: 10.1242/jcs.051011. J Cell Sci. 2009. PMID: 19812304 Free PMC article. Review. No abstract available.
287 results