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Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen.
Duvall JR, VerPlank L, Ludeke B, McLeod SM, Lee MD 4th, Vishwanathan K, Mulrooney CA, Le Quement S, Yu Q, Palmer MA, Fleming P, Fearns R, Foley MA, Scherer CA. Duvall JR, et al. Antiviral Res. 2016 Jul;131:19-25. doi: 10.1016/j.antiviral.2016.03.015. Epub 2016 Apr 6. Antiviral Res. 2016. PMID: 27059228 Free PMC article.
Novel broad-spectrum inhibitors of bacterial methionine aminopeptidase.
Rose JA, Lahiri SD, McKinney DC, Albert R, Morningstar ML, Shapiro AB, Fisher SL, Fleming PR. Rose JA, et al. Among authors: fleming pr. Bioorg Med Chem Lett. 2015 Aug 15;25(16):3301-6. doi: 10.1016/j.bmcl.2015.05.061. Epub 2015 May 30. Bioorg Med Chem Lett. 2015. PMID: 26099541
Pyrazolopyrimidines establish MurC as a vulnerable target in Pseudomonas aeruginosa and Escherichia coli.
Hameed P S, Manjrekar P, Chinnapattu M, Humnabadkar V, Shanbhag G, Kedari C, Mudugal NV, Ambady A, de Jonge BL, Sadler C, Paul B, Sriram S, Kaur P, Guptha S, Raichurkar A, Fleming P, Eyermann CJ, McKinney DC, Sambandamurthy VK, Panda M, Ravishankar S. Hameed P S, et al. ACS Chem Biol. 2014 Oct 17;9(10):2274-82. doi: 10.1021/cb500360c. Epub 2014 Aug 5. ACS Chem Biol. 2014. PMID: 25035921
Discovery of a potent respiratory syncytial virus RNA polymerase inhibitor.
Xiong H, Foulk M, Aschenbrenner L, Fan J, Tiong-Yip CL, Johnson KD, Moustakas D, Fleming PR, Brown DG, Zhang M, Ferguson D, Wu D, Yu Q. Xiong H, et al. Among authors: fleming pr. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6789-93. doi: 10.1016/j.bmcl.2013.10.018. Epub 2013 Oct 16. Bioorg Med Chem Lett. 2013. PMID: 24211022
X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein.
Molodtsov V, Fleming PR, Eyermann CJ, Ferguson AD, Foulk MA, McKinney DC, Masse CE, Buurman ET, Murakami KS. Molodtsov V, et al. Among authors: fleming pr. J Med Chem. 2015 Apr 9;58(7):3156-71. doi: 10.1021/acs.jmedchem.5b00050. Epub 2015 Mar 23. J Med Chem. 2015. PMID: 25798859 Free PMC article.
54 results