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Cellular postconditioning: allogeneic cardiosphere-derived cells reduce infarct size and attenuate microvascular obstruction when administered after reperfusion in pigs with acute myocardial infarction.
Kanazawa H, Tseliou E, Malliaras K, Yee K, Dawkins JF, De Couto G, Smith RR, Kreke M, Seinfeld J, Middleton RC, Gallet R, Cheng K, Luthringer D, Valle I, Chowdhury S, Fukuda K, Makkar RR, Marbán L, Marbán E. Kanazawa H, et al. Among authors: middleton rc. Circ Heart Fail. 2015 Mar;8(2):322-32. doi: 10.1161/CIRCHEARTFAILURE.114.001484. Epub 2015 Jan 13. Circ Heart Fail. 2015. PMID: 25587096 Free PMC article.
c-kit+ cells minimally contribute cardiomyocytes to the heart.
van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SC, Middleton RC, Marbán E, Molkentin JD. van Berlo JH, et al. Among authors: middleton rc. Nature. 2014 May 15;509(7500):337-41. doi: 10.1038/nature13309. Epub 2014 May 7. Nature. 2014. PMID: 24805242 Free PMC article.
Allogeneic cardiospheres delivered via percutaneous transendocardial injection increase viable myocardium, decrease scar size, and attenuate cardiac dilatation in porcine ischemic cardiomyopathy.
Yee K, Malliaras K, Kanazawa H, Tseliou E, Cheng K, Luthringer DJ, Ho CS, Takayama K, Minamino N, Dawkins JF, Chowdhury S, Duong DT, Seinfeld J, Middleton RC, Dharmakumar R, Li D, Marbán L, Makkar RR, Marbán E. Yee K, et al. Among authors: middleton rc. PLoS One. 2014 Dec 2;9(12):e113805. doi: 10.1371/journal.pone.0113805. eCollection 2014. PLoS One. 2014. PMID: 25460005 Free PMC article.
Intracoronary delivery of self-assembling heart-derived microtissues (cardiospheres) for prevention of adverse remodeling in a pig model of convalescent myocardial infarction.
Gallet R, Tseliou E, Dawkins J, Middleton R, Valle J, Angert D, Reich H, Luthringer D, Kreke M, Smith R, Marbán L, Marbán E. Gallet R, et al. Circ Cardiovasc Interv. 2015 May;8(5):10.1161/CIRCINTERVENTIONS.115.002391 e002391. doi: 10.1161/CIRCINTERVENTIONS.115.002391. Circ Cardiovasc Interv. 2015. PMID: 25953823 Free PMC article.
Widespread Myocardial Delivery of Heart-Derived Stem Cells by Nonocclusive Triple-Vessel Intracoronary Infusion in Porcine Ischemic Cardiomyopathy: Superior Attenuation of Adverse Remodeling Documented by Magnetic Resonance Imaging and Histology.
Tseliou E, Kanazawa H, Dawkins J, Gallet R, Kreke M, Smith R, Middleton R, Valle J, Marbán L, Kar S, Makkar R, Marbán E. Tseliou E, et al. PLoS One. 2016 Jan 19;11(1):e0144523. doi: 10.1371/journal.pone.0144523. eCollection 2016. PLoS One. 2016. PMID: 26784932 Free PMC article.
Durable Benefits of Cellular Postconditioning: Long-Term Effects of Allogeneic Cardiosphere-Derived Cells Infused After Reperfusion in Pigs with Acute Myocardial Infarction.
Kanazawa H, Tseliou E, Dawkins JF, De Couto G, Gallet R, Malliaras K, Yee K, Kreke M, Valle I, Smith RR, Middleton RC, Ho CS, Dharmakumar R, Li D, Makkar RR, Fukuda K, Marbán L, Marbán E. Kanazawa H, et al. Among authors: middleton rc. J Am Heart Assoc. 2016 Feb 8;5(2):e002796. doi: 10.1161/JAHA.115.002796. J Am Heart Assoc. 2016. PMID: 26857066 Free PMC article.
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