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Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis.
Zhang Y, Cook A, Kim J, Baranov SV, Jiang J, Smith K, Cormier K, Bennett E, Browser RP, Day AL, Carlisle DL, Ferrante RJ, Wang X, Friedlander RM. Zhang Y, et al. Among authors: wang x. Neurobiol Dis. 2013 Jul;55:26-35. doi: 10.1016/j.nbd.2013.03.008. Epub 2013 Mar 26. Neurobiol Dis. 2013. PMID: 23537713 Free PMC article.
Nortriptyline delays disease onset in models of chronic neurodegeneration.
Wang H, Guan Y, Wang X, Smith K, Cormier K, Zhu S, Stavrovskaya IG, Huo C, Ferrante RJ, Kristal BS, Friedlander RM. Wang H, et al. Among authors: wang x. Eur J Neurosci. 2007 Aug;26(3):633-41. doi: 10.1111/j.1460-9568.2007.05663.x. Eur J Neurosci. 2007. PMID: 17686041
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