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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM. Sancak Y, et al. Among authors: sabatini dm. Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22. Science. 2008. PMID: 18497260 Free PMC article.
Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling.
Lindquist RA, Ottina KA, Wheeler DB, Hsu PP, Thoreen CC, Guertin DA, Ali SM, Sengupta S, Shaul YD, Lamprecht MR, Madden KL, Papallo AR, Jones TR, Sabatini DM, Carpenter AE. Lindquist RA, et al. Among authors: sabatini dm. Genome Res. 2011 Mar;21(3):433-46. doi: 10.1101/gr.111492.110. Epub 2011 Jan 14. Genome Res. 2011. PMID: 21239477 Free PMC article.
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, Chen WW, Barrett FG, Stransky N, Tsun ZY, Cowley GS, Barretina J, Kalaany NY, Hsu PP, Ottina K, Chan AM, Yuan B, Garraway LA, Root DE, Mino-Kenudson M, Brachtel EF, Driggers EM, Sabatini DM. Possemato R, et al. Among authors: sabatini dm. Nature. 2011 Aug 18;476(7360):346-50. doi: 10.1038/nature10350. Nature. 2011. PMID: 21760589 Free PMC article.
ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.
Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, Nishimura R, Sakata N, Fine HA, Carpenter AE, Silver SJ, Verhaak RG, Califano A, Young RA, Ligon KL, Mellinghoff IK, Root DE, Sabatini DM, Hahn WC, Chheda MG. Chudnovsky Y, et al. Among authors: sabatini dm. Cell Rep. 2014 Jan 30;6(2):313-24. doi: 10.1016/j.celrep.2013.12.032. Epub 2014 Jan 16. Cell Rep. 2014. PMID: 24440720 Free PMC article.
Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.
Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM. Shaul YD, et al. Among authors: sabatini dm. Cell. 2014 Aug 28;158(5):1094-1109. doi: 10.1016/j.cell.2014.07.032. Cell. 2014. PMID: 25171410 Free PMC article.
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.
Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, Lamming DW, Dogum R, Guo G, Bell GW, Selig M, Nielsen GP, Gupta N, Ferrone CR, Deshpande V, Yuan GC, Orkin SH, Sabatini DM, Yilmaz ÖH. Beyaz S, et al. Among authors: sabatini dm. Nature. 2016 Mar 3;531(7592):53-8. doi: 10.1038/nature17173. Nature. 2016. PMID: 26935695 Free PMC article.
287 results