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Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma.
Okosun J, Wolfson RL, Wang J, Araf S, Wilkins L, Castellano BM, Escudero-Ibarz L, Al Seraihi AF, Richter J, Bernhart SH, Efeyan A, Iqbal S, Matthews J, Clear A, Guerra-Assunção JA, Bödör C, Quentmeier H, Mansbridge C, Johnson P, Davies A, Strefford JC, Packham G, Barrans S, Jack A, Du MQ, Calaminici M, Lister TA, Auer R, Montoto S, Gribben JG, Siebert R, Chelala C, Zoncu R, Sabatini DM, Fitzgibbon J. Okosun J, et al. Among authors: sabatini dm. Nat Genet. 2016 Feb;48(2):183-8. doi: 10.1038/ng.3473. Epub 2015 Dec 21. Nat Genet. 2016. PMID: 26691987 Free PMC article.
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM. Sancak Y, et al. Among authors: sabatini dm. Mol Cell. 2007 Mar 23;25(6):903-15. doi: 10.1016/j.molcel.2007.03.003. Mol Cell. 2007. PMID: 17386266 Free article.
Increased mTORC1 signaling UPRegulates stress.
Reiling JH, Sabatini DM. Reiling JH, et al. Among authors: sabatini dm. Mol Cell. 2008 Mar 14;29(5):533-5. doi: 10.1016/j.molcel.2008.02.011. Mol Cell. 2008. PMID: 18342598 Free article.
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.
Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM. Sancak Y, et al. Among authors: sabatini dm. Science. 2008 Jun 13;320(5882):1496-501. doi: 10.1126/science.1157535. Epub 2008 May 22. Science. 2008. PMID: 18497260 Free PMC article.
Rapamycin inhibits mTORC1, but not completely.
Thoreen CC, Sabatini DM. Thoreen CC, et al. Among authors: sabatini dm. Autophagy. 2009 Jul;5(5):725-6. doi: 10.4161/auto.5.5.8504. Epub 2009 Jul 22. Autophagy. 2009. PMID: 19395872
mTOR and cancer: many loops in one pathway.
Efeyan A, Sabatini DM. Efeyan A, et al. Among authors: sabatini dm. Curr Opin Cell Biol. 2010 Apr;22(2):169-76. doi: 10.1016/j.ceb.2009.10.007. Epub 2009 Nov 27. Curr Opin Cell Biol. 2010. PMID: 19945836 Free PMC article.
287 results