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Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3.
Gao R, Liu Y, Silva-Fernandes A, Fang X, Paulucci-Holthauzen A, Chatterjee A, Zhang HL, Matsuura T, Choudhary S, Ashizawa T, Koeppen AH, Maciel P, Hazra TK, Sarkar PS. Gao R, et al. Among authors: sarkar ps. PLoS Genet. 2015 Jan 15;11(1):e1004834. doi: 10.1371/journal.pgen.1004834. eCollection 2015 Jan. PLoS Genet. 2015. PMID: 25590633 Free PMC article.
Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.
Gao R, Chakraborty A, Geater C, Pradhan S, Gordon KL, Snowden J, Yuan S, Dickey AS, Choudhary S, Ashizawa T, Ellerby LM, La Spada AR, Thompson LM, Hazra TK, Sarkar PS. Gao R, et al. Among authors: sarkar ps. Elife. 2019 Apr 17;8:e42988. doi: 10.7554/eLife.42988. Elife. 2019. PMID: 30994454 Free PMC article.
Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome.
Mandal SM, Hegde ML, Chatterjee A, Hegde PM, Szczesny B, Banerjee D, Boldogh I, Gao R, Falkenberg M, Gustafsson CM, Sarkar PS, Hazra TK. Mandal SM, et al. Among authors: sarkar ps. J Biol Chem. 2012 Jan 20;287(4):2819-29. doi: 10.1074/jbc.M111.272179. Epub 2011 Nov 30. J Biol Chem. 2012. PMID: 22130663 Free PMC article.
Myotonic dystrophy types 1 and 2.
Ashizawa T, Sarkar PS. Ashizawa T, et al. Among authors: sarkar ps. Handb Clin Neurol. 2011;101:193-237. doi: 10.1016/B978-0-08-045031-5.00015-3. Handb Clin Neurol. 2011. PMID: 21496635 Review.
60 results