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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation.
Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, Fitz LJ, Malenkovich N, Okazaki T, Byrne MC, Horton HF, Fouser L, Carter L, Ling V, Bowman MR, Carreno BM, Collins M, Wood CR, Honjo T. Freeman GJ, et al. J Exp Med. 2000 Oct 2;192(7):1027-34. doi: 10.1084/jem.192.7.1027. J Exp Med. 2000. PMID: 11015443 Free PMC article.
Tissue expression of PD-L1 mediates peripheral T cell tolerance.
Keir ME, Liang SC, Guleria I, Latchman YE, Qipo A, Albacker LA, Koulmanda M, Freeman GJ, Sayegh MH, Sharpe AH. Keir ME, et al. Among authors: freeman gj. J Exp Med. 2006 Apr 17;203(4):883-95. doi: 10.1084/jem.20051776. Epub 2006 Apr 10. J Exp Med. 2006. PMID: 16606670 Free PMC article.
Interaction of human PD-L1 and B7-1.
Butte MJ, Peña-Cruz V, Kim MJ, Freeman GJ, Sharpe AH. Butte MJ, et al. Among authors: freeman gj. Mol Immunol. 2008 Aug;45(13):3567-72. doi: 10.1016/j.molimm.2008.05.014. Epub 2008 Jun 27. Mol Immunol. 2008. PMID: 18585785 Free PMC article.
Role of PD-1 in regulating acute infections.
Brown KE, Freeman GJ, Wherry EJ, Sharpe AH. Brown KE, et al. Among authors: freeman gj. Curr Opin Immunol. 2010 Jun;22(3):397-401. doi: 10.1016/j.coi.2010.03.007. Epub 2010 Apr 27. Curr Opin Immunol. 2010. PMID: 20427170 Free PMC article. Review.
Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF.
Quigley M, Pereyra F, Nilsson B, Porichis F, Fonseca C, Eichbaum Q, Julg B, Jesneck JL, Brosnahan K, Imam S, Russell K, Toth I, Piechocka-Trocha A, Dolfi D, Angelosanto J, Crawford A, Shin H, Kwon DS, Zupkosky J, Francisco L, Freeman GJ, Wherry EJ, Kaufmann DE, Walker BD, Ebert B, Haining WN. Quigley M, et al. Among authors: freeman gj. Nat Med. 2010 Oct;16(10):1147-51. doi: 10.1038/nm.2232. Epub 2010 Oct 3. Nat Med. 2010. PMID: 20890291 Free PMC article.
443 results