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LRRK2 levels in immune cells are increased in Parkinson's disease.
Cook DA, Kannarkat GT, Cintron AF, Butkovich LM, Fraser KB, Chang J, Grigoryan N, Factor SA, West AB, Boss JM, Tansey MG. Cook DA, et al. Among authors: west ab. NPJ Parkinsons Dis. 2017 Mar 28;3:11. doi: 10.1038/s41531-017-0010-8. eCollection 2017. NPJ Parkinsons Dis. 2017. PMID: 28649611 Free PMC article.
LRRK2 secretion in exosomes is regulated by 14-3-3.
Fraser KB, Moehle MS, Daher JP, Webber PJ, Williams JY, Stewart CA, Yacoubian TA, Cowell RM, Dokland T, Ye T, Chen D, Siegal GP, Galemmo RA, Tsika E, Moore DJ, Standaert DG, Kojima K, Mobley JA, West AB. Fraser KB, et al. Among authors: west ab. Hum Mol Genet. 2013 Dec 15;22(24):4988-5000. doi: 10.1093/hmg/ddt346. Epub 2013 Jul 25. Hum Mol Genet. 2013. PMID: 23886663 Free PMC article.
Unique functional and structural properties of the LRRK2 protein ATP-binding pocket.
Liu Z, Galemmo RA Jr, Fraser KB, Moehle MS, Sen S, Volpicelli-Daley LA, DeLucas LJ, Ross LJ, Valiyaveettil J, Moukha-Chafiq O, Pathak AK, Ananthan S, Kezar H, White EL, Gupta V, Maddry JA, Suto MJ, West AB. Liu Z, et al. Among authors: west ab. J Biol Chem. 2014 Nov 21;289(47):32937-51. doi: 10.1074/jbc.M114.602318. Epub 2014 Sep 16. J Biol Chem. 2014. PMID: 25228699 Free PMC article.
G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons.
Volpicelli-Daley LA, Abdelmotilib H, Liu Z, Stoyka L, Daher JP, Milnerwood AJ, Unni VK, Hirst WD, Yue Z, Zhao HT, Fraser K, Kennedy RE, West AB. Volpicelli-Daley LA, et al. Among authors: west ab. J Neurosci. 2016 Jul 13;36(28):7415-27. doi: 10.1523/JNEUROSCI.3642-15.2016. J Neurosci. 2016. PMID: 27413152 Free PMC article.
264 results