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Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.
Blandino-Rosano M, Barbaresso R, Jimenez-Palomares M, Bozadjieva N, Werneck-de-Castro JP, Hatanaka M, Mirmira RG, Sonenberg N, Liu M, Rüegg MA, Hall MN, Bernal-Mizrachi E. Blandino-Rosano M, et al. Among authors: liu m. Nat Commun. 2017 Jul 12;8:16014. doi: 10.1038/ncomms16014. Nat Commun. 2017. PMID: 28699639 Free PMC article.
Maternal diet-induced microRNAs and mTOR underlie β cell dysfunction in offspring.
Alejandro EU, Gregg B, Wallen T, Kumusoglu D, Meister D, Chen A, Merrins MJ, Satin LS, Liu M, Arvan P, Bernal-Mizrachi E. Alejandro EU, et al. Among authors: liu m. J Clin Invest. 2014 Oct;124(10):4395-410. doi: 10.1172/JCI74237. Epub 2014 Sep 2. J Clin Invest. 2014. PMID: 25180600 Free PMC article.
Molecular aspects of pancreatic beta cell failure and diabetes.
Arvan P, Bernal-Mizrachi E, Liu M, Pietropaolo M, Satin L, Schnell S, Soleimanpour SA. Arvan P, et al. Among authors: liu m. Mol Aspects Med. 2015 Apr;42:1-2. doi: 10.1016/j.mam.2015.01.002. Epub 2015 Jan 14. Mol Aspects Med. 2015. PMID: 25596327 No abstract available.
Autophagy is a major regulator of beta cell insulin homeostasis.
Riahi Y, Wikstrom JD, Bachar-Wikstrom E, Polin N, Zucker H, Lee MS, Quan W, Haataja L, Liu M, Arvan P, Cerasi E, Leibowitz G. Riahi Y, et al. Among authors: liu m. Diabetologia. 2016 Jul;59(7):1480-1491. doi: 10.1007/s00125-016-3868-9. Epub 2016 Jan 30. Diabetologia. 2016. PMID: 26831301 Free PMC article.
4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass.
Blandino-Rosano M, Scheys JO, Jimenez-Palomares M, Barbaresso R, Bender AS, Yanagiya A, Liu M, Rui L, Sonenberg N, Bernal-Mizrachi E. Blandino-Rosano M, et al. Among authors: liu m. Diabetes. 2016 Aug;65(8):2235-48. doi: 10.2337/db15-1443. Epub 2016 May 23. Diabetes. 2016. PMID: 27217487 Free PMC article.
Misfolded proinsulin impairs processing of precursor of insulin receptor and insulin signaling in β cells.
Liu S, Li X, Yang J, Zhu R, Fan Z, Xu X, Feng W, Cui J, Sun J, Liu M. Liu S, et al. Among authors: liu m. FASEB J. 2019 Oct;33(10):11338-11348. doi: 10.1096/fj.201900442R. Epub 2019 Aug 1. FASEB J. 2019. PMID: 31311313 Free PMC article.
These results reveal for the first time that misfolded proinsulin can interact with ProIR in the ER, impairing intracellular processing of ProIR and leading to defective insulin signaling that may contribute to beta-cell failure in both MIDY and T2D.-Liu, S., Li, X., Yang, …
These results reveal for the first time that misfolded proinsulin can interact with ProIR in the ER, impairing intracellular processing of P …
Neuronatin regulates pancreatic β cell insulin content and secretion.
Millership SJ, Da Silva Xavier G, Choudhury AI, Bertazzo S, Chabosseau P, Pedroni SM, Irvine EE, Montoya A, Faull P, Taylor WR, Kerr-Conte J, Pattou F, Ferrer J, Christian M, John RM, Latreille M, Liu M, Rutter GA, Scott J, Withers DJ. Millership SJ, et al. Among authors: liu m. J Clin Invest. 2018 Aug 1;128(8):3369-3381. doi: 10.1172/JCI120115. Epub 2018 Jul 9. J Clin Invest. 2018. PMID: 29864031 Free PMC article.
Biosynthesis, structure, and folding of the insulin precursor protein.
Liu M, Weiss MA, Arunagiri A, Yong J, Rege N, Sun J, Haataja L, Kaufman RJ, Arvan P. Liu M, et al. Diabetes Obes Metab. 2018 Sep;20 Suppl 2(Suppl 2):28-50. doi: 10.1111/dom.13378. Diabetes Obes Metab. 2018. PMID: 30230185 Free PMC article. Review.
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