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Hypusine biosynthesis in β cells links polyamine metabolism to facultative cellular proliferation to maintain glucose homeostasis.
Levasseur EM, Yamada K, Piñeros AR, Wu W, Syed F, Orr KS, Anderson-Baucum E, Mastracci TL, Maier B, Mosley AL, Liu Y, Bernal-Mizrachi E, Alonso LC, Scott D, Garcia-Ocaña A, Tersey SA, Mirmira RG. Levasseur EM, et al. Sci Signal. 2019 Dec 3;12(610):eaax0715. doi: 10.1126/scisignal.aax0715. Sci Signal. 2019. PMID: 31796630 Free PMC article.
Human β-cell proliferation and intracellular signaling: part 3.
Stewart AF, Hussain MA, García-Ocaña A, Vasavada RC, Bhushan A, Bernal-Mizrachi E, Kulkarni RN. Stewart AF, et al. Diabetes. 2015 Jun;64(6):1872-85. doi: 10.2337/db14-1843. Diabetes. 2015. PMID: 25999530 Free PMC article. Review.
Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing.
Blandino-Rosano M, Barbaresso R, Jimenez-Palomares M, Bozadjieva N, Werneck-de-Castro JP, Hatanaka M, Mirmira RG, Sonenberg N, Liu M, Rüegg MA, Hall MN, Bernal-Mizrachi E. Blandino-Rosano M, et al. Nat Commun. 2017 Jul 12;8:16014. doi: 10.1038/ncomms16014. Nat Commun. 2017. PMID: 28699639 Free PMC article.
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.
Skovsø S, Panzhinskiy E, Kolic J, Cen HH, Dionne DA, Dai XQ, Sharma RB, Elghazi L, Ellis CE, Faulkner K, Marcil SAM, Overby P, Noursadeghi N, Hutchinson D, Hu X, Li H, Modi H, Wildi JS, Botezelli JD, Noh HL, Suk S, Gablaski B, Bautista A, Kim R, Cras-Méneur C, Flibotte S, Sinha S, Luciani DS, Nislow C, Rideout EJ, Cytrynbaum EN, Kim JK, Bernal-Mizrachi E, Alonso LC, MacDonald PE, Johnson JD. Skovsø S, et al. Nat Commun. 2022 Feb 8;13(1):735. doi: 10.1038/s41467-022-28039-8. Nat Commun. 2022. PMID: 35136059 Free PMC article.
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings.
Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M. Mastracci TL, et al. Diabetes. 2023 Apr 1;72(4):433-448. doi: 10.2337/db22-0942. Diabetes. 2023. PMID: 36940317 Free PMC article. Review.
Importance of β-Catenin in glucose and energy homeostasis.
Elghazi L, Gould AP, Weiss AJ, Barker DJ, Callaghan J, Opland D, Myers M, Cras-Méneur C, Bernal-Mizrachi E. Elghazi L, et al. Sci Rep. 2012;2:693. doi: 10.1038/srep00693. Epub 2012 Sep 25. Sci Rep. 2012. PMID: 23012647 Free PMC article.
Cyclin C stimulates β-cell proliferation in rat and human pancreatic β-cells.
Jiménez-Palomares M, López-Acosta JF, Villa-Pérez P, Moreno-Amador JL, Muñoz-Barrera J, Fernández-Luis S, Heras-Pozas B, Perdomo G, Bernal-Mizrachi E, Cózar-Castellano I. Jiménez-Palomares M, et al. Am J Physiol Endocrinol Metab. 2015 Mar 15;308(6):E450-9. doi: 10.1152/ajpendo.00260.2014. Epub 2015 Jan 6. Am J Physiol Endocrinol Metab. 2015. PMID: 25564474 Free PMC article.
100 results